99mTc-HMPAO-labeled WBC scan for the diagnosis of chronic recurrent multifocal osteomyelitis

Tyler A. Dailey, Michael D. Berven, Penny J. Vroman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The goal of this teaching case study is to demonstrate the novel use of 99mTc-HMPAO-labeled white blood cells (WBCs) in diagnosing chronic recurrent multifocal osteomyelitis (CRMO). 99mTc-HMPAO-labeled white blood cells were utilized to diagnose CRMO. Classically, CRMO is evaluated scintigraphically using 99mTc-methylene diphosphonate/hydroxymethylene diphosphonate. 99mTc-HMPAO-labeled WBCs were chosen over 111In-labeled WBCs because of the former's improved imaging characteristics and decreased radiation dose. 99mTc- HMPAO-labeled WBCs were successful in diagnosing CRMO. 99mTc-HMPAO-labeled WBC scanning is specific for the diagnosis of CRMO.

Original languageEnglish (US)
Pages (from-to)299-301
Number of pages3
JournalJournal of Nuclear Medicine Technology
Issue number4
StatePublished - 2014
Externally publishedYes


  • Bone scan
  • Chronic recurrent multifocal osteomyelitis
  • Pediatric

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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