[3H]Nicotine binding sites in developing fetal brains in rats

Hiroyuki Sugiyama, Nobuyoshi Hagino, Gary Moore, John W. Lee

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

[3H]Nicotine binding sites were examined in developing fetal brains in rats. The fetal brain membranes bound [3H]nicotine with a similar affinity to that of adult brain membranes. This binding was displaced by unlabelled nicotine or carbamylcholine, the inhibition concentrations being approximately the same for fetal and adult brain preparations. α-Bungarotoxin had no effect on [3H]nicotine binding to fetal brain membranes as well as to adult brain preparations. The specific [3H]nicotine binding was first detectable on day 16 of gestation and it increased several folds until birth.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalNeuroscience Research
Volume2
Issue number5
DOIs
StatePublished - Jun 1985
Externally publishedYes

Keywords

  • acetylcholine receptor
  • central nervous system
  • fetal brain
  • fetal development
  • nicotine
  • α-bungarotoxin

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of '[3H]Nicotine binding sites in developing fetal brains in rats'. Together they form a unique fingerprint.

Cite this