19F magnetic resonance imaging and spectroscopy of a fluorinated neuroleptic ligand: In vivo and in vitro studies

David C. Arndt, Adam V. Ratner, Kym F. Faull, Jack D. Barchas, Stuart W. Young

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The bulk biodistribution of a trifluorinated neuroleptic (fluphenazine) was studied using 19F magnetic resonance imaging (MRI). Fifteen male Sprague-Dawley rats were injected with fluphenazine (120 mg/kg) and scanned in a G.E. CSI 2.0 tesla MRI system. The rats were killed following scanning and the brains were removed. The excised brains were then scanned using 1H and 19F MR techniques. The fluorinated neuroleptic was imaged at the injection site, spectroscopically detected in vivo in the head, and spectroscopically localized in the whole brain. These data suggest that in vivo 19F MRI of fluorinated agents is possible and could have clinical and research applications to the neurosciences.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalPsychiatry Research
Volume25
Issue number1
DOIs
StatePublished - Jul 1988
Externally publishedYes

Keywords

  • Magnetic resonance imaging and spectroscopy
  • dopamine
  • fluorine
  • imaging
  • neuroleptics
  • neuroreceptors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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