Suicide attempts in major depressive episode: Evidence from the BRIDGE-II-Mix study

BRIDGE-II-Mix Study Group

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objectives: The Bipolar Disorders: Improving Diagnosis, Guidance, and Education (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as suicidality. Methods: A total of 2,811 subjects were enrolled in this multicenter cross-sectional study. Psychiatric symptoms, and sociodemographic and clinical variables were collected. The analysis compared the characteristics of patients with MDE with (MDE-SA group) and without (MDE-NSA) a history of suicide attempts. Results: The history of suicide attempts was registered in 628 patients (22.34%). In the MDE-SA group, women (72.5%, p = 0.028), (hypo)mania in first-degree relatives (20.5%, p <0.0001), psychotic features (15.1%, p <0.0001), and atypical features (9.2%, p = 0.009) were more prevalent. MDE-SA patients' previous responses to treatment with antidepressants included more (hypo)manic switches [odds ratio (OR) = 1.97, 95% confidence interval (CI): 1.58-2.44, p <0.0001], treatment resistance (OR = 2.07, 95% CI: 1.72-2.49, p <0.0001), mood lability (OR = 1.98, 95% CI: 1.65-2.39, p <0.0001), and irritability (OR = 1.80, 95% CI: 1.48-2.17, p <0.0001). Multivariate analysis evidenced that risky behavior, psychomotor agitation and impulsivity, and borderline personality and substance use disorders were the variables most frequently associated with previous suicide attempts. In the MDE-SA group, 75 patients (11.9%) fulfilled Diagnostic and Statistical Manual (DSM)-5 criteria for MDE with mixed features, and 250 patients (39.8%) fulfilled research-based diagnostic criteria for a mixed depressive episode. Conclusions: Important differences between MDE-SA and MDE-NSA patients have emerged. Early identification of symptoms such as risky behavior, psychomotor agitation, and impulsivity in patients with MDE, and treatment of mixed depressive states could represent a major step in suicide prevention.

Original languageEnglish (US)
Pages (from-to)795-803
Number of pages9
JournalBipolar Disorders
Volume17
Issue number7
DOIs
StatePublished - Nov 1 2015

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Suicide
Odds Ratio
Confidence Intervals
Psychomotor Agitation
Impulsive Behavior
Bipolar Disorder
Antidepressive Agents
Substance-Related Disorders
Psychiatry
Personality
Therapeutics
Multivariate Analysis
Cross-Sectional Studies
History
Education
Research

Keywords

  • Bipolar disorder
  • Mixed features
  • Suicide attempts

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Suicide attempts in major depressive episode : Evidence from the BRIDGE-II-Mix study. / BRIDGE-II-Mix Study Group.

In: Bipolar Disorders, Vol. 17, No. 7, 01.11.2015, p. 795-803.

Research output: Contribution to journalArticle

BRIDGE-II-Mix Study Group. / Suicide attempts in major depressive episode : Evidence from the BRIDGE-II-Mix study. In: Bipolar Disorders. 2015 ; Vol. 17, No. 7. pp. 795-803.
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abstract = "Objectives: The Bipolar Disorders: Improving Diagnosis, Guidance, and Education (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as suicidality. Methods: A total of 2,811 subjects were enrolled in this multicenter cross-sectional study. Psychiatric symptoms, and sociodemographic and clinical variables were collected. The analysis compared the characteristics of patients with MDE with (MDE-SA group) and without (MDE-NSA) a history of suicide attempts. Results: The history of suicide attempts was registered in 628 patients (22.34{\%}). In the MDE-SA group, women (72.5{\%}, p = 0.028), (hypo)mania in first-degree relatives (20.5{\%}, p <0.0001), psychotic features (15.1{\%}, p <0.0001), and atypical features (9.2{\%}, p = 0.009) were more prevalent. MDE-SA patients' previous responses to treatment with antidepressants included more (hypo)manic switches [odds ratio (OR) = 1.97, 95{\%} confidence interval (CI): 1.58-2.44, p <0.0001], treatment resistance (OR = 2.07, 95{\%} CI: 1.72-2.49, p <0.0001), mood lability (OR = 1.98, 95{\%} CI: 1.65-2.39, p <0.0001), and irritability (OR = 1.80, 95{\%} CI: 1.48-2.17, p <0.0001). Multivariate analysis evidenced that risky behavior, psychomotor agitation and impulsivity, and borderline personality and substance use disorders were the variables most frequently associated with previous suicide attempts. In the MDE-SA group, 75 patients (11.9{\%}) fulfilled Diagnostic and Statistical Manual (DSM)-5 criteria for MDE with mixed features, and 250 patients (39.8{\%}) fulfilled research-based diagnostic criteria for a mixed depressive episode. Conclusions: Important differences between MDE-SA and MDE-NSA patients have emerged. Early identification of symptoms such as risky behavior, psychomotor agitation, and impulsivity in patients with MDE, and treatment of mixed depressive states could represent a major step in suicide prevention.",
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author = "{BRIDGE-II-Mix Study Group} and Dina Popovic and Eduard Vieta and Azorin, {Jean Michel} and Jules Angst and Bowden, {Charles L.} and Sergey Mosolov and Young, {Allan H.} and Giulio Perugi",
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AU - BRIDGE-II-Mix Study Group

AU - Popovic, Dina

AU - Vieta, Eduard

AU - Azorin, Jean Michel

AU - Angst, Jules

AU - Bowden, Charles L.

AU - Mosolov, Sergey

AU - Young, Allan H.

AU - Perugi, Giulio

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N2 - Objectives: The Bipolar Disorders: Improving Diagnosis, Guidance, and Education (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as suicidality. Methods: A total of 2,811 subjects were enrolled in this multicenter cross-sectional study. Psychiatric symptoms, and sociodemographic and clinical variables were collected. The analysis compared the characteristics of patients with MDE with (MDE-SA group) and without (MDE-NSA) a history of suicide attempts. Results: The history of suicide attempts was registered in 628 patients (22.34%). In the MDE-SA group, women (72.5%, p = 0.028), (hypo)mania in first-degree relatives (20.5%, p <0.0001), psychotic features (15.1%, p <0.0001), and atypical features (9.2%, p = 0.009) were more prevalent. MDE-SA patients' previous responses to treatment with antidepressants included more (hypo)manic switches [odds ratio (OR) = 1.97, 95% confidence interval (CI): 1.58-2.44, p <0.0001], treatment resistance (OR = 2.07, 95% CI: 1.72-2.49, p <0.0001), mood lability (OR = 1.98, 95% CI: 1.65-2.39, p <0.0001), and irritability (OR = 1.80, 95% CI: 1.48-2.17, p <0.0001). Multivariate analysis evidenced that risky behavior, psychomotor agitation and impulsivity, and borderline personality and substance use disorders were the variables most frequently associated with previous suicide attempts. In the MDE-SA group, 75 patients (11.9%) fulfilled Diagnostic and Statistical Manual (DSM)-5 criteria for MDE with mixed features, and 250 patients (39.8%) fulfilled research-based diagnostic criteria for a mixed depressive episode. Conclusions: Important differences between MDE-SA and MDE-NSA patients have emerged. Early identification of symptoms such as risky behavior, psychomotor agitation, and impulsivity in patients with MDE, and treatment of mixed depressive states could represent a major step in suicide prevention.

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