TY - JOUR
T1 - Suicidality in temporal lobe epilepsy
T2 - Measuring the weight of impulsivity and depression
AU - De Oliveira, Guilherme Nogueira M.
AU - Kummer, Arthur
AU - Salgado, João Vinícius
AU - Filho, Gerardo Maria de Araújo
AU - David, Anthony S.
AU - Teixeira, Ant Ônio Lúcio
PY - 2011/12
Y1 - 2011/12
N2 - Objective: The aim of the work described here was to measure the role of psychopathological features, specifically impulsivity and depression, in suicidality in patients with temporal lobe epilepsy (TLE). Methods: Neuropsychiatric evaluation of 66 outpatients with TLE was performed with the following instruments: a structured clinical interview (Mini International Neuropsychiatric Interview Plus), the Barratt Impulsiveness Scale, the Hamilton Anxiety Scale, the Beck Depression Inventory, and the Brief Psychiatric Rating Scale. Results: A current Axis I psychiatric diagnosis, mainly mood and anxiety disorders, was assigned to 37 subjects (56.1%) Presence of suicide risk was identified in 19 patients (28.8%), and 14 (21.2%) had attempted suicide. Frequency of seizures (P= 0.012), current major depression (P= 0.001), and motor impulsivity (P= 0.005) were associated with suicide risk on univariate analysis. Logistic regression stressed the main relevance of major depression (OR = 12.82, 95% CI = 2.58-63.76, P= 0.002) and motor impulsivity (OR = 1.21, 95% CI = 1.06-1.38, P= 0.005) to suicide risk. Conclusion: Depression has a major influence on suicidality in epilepsy. Motor impulsivity is also relevant and may be an important component of depression in TLE associated with suicide risk.
AB - Objective: The aim of the work described here was to measure the role of psychopathological features, specifically impulsivity and depression, in suicidality in patients with temporal lobe epilepsy (TLE). Methods: Neuropsychiatric evaluation of 66 outpatients with TLE was performed with the following instruments: a structured clinical interview (Mini International Neuropsychiatric Interview Plus), the Barratt Impulsiveness Scale, the Hamilton Anxiety Scale, the Beck Depression Inventory, and the Brief Psychiatric Rating Scale. Results: A current Axis I psychiatric diagnosis, mainly mood and anxiety disorders, was assigned to 37 subjects (56.1%) Presence of suicide risk was identified in 19 patients (28.8%), and 14 (21.2%) had attempted suicide. Frequency of seizures (P= 0.012), current major depression (P= 0.001), and motor impulsivity (P= 0.005) were associated with suicide risk on univariate analysis. Logistic regression stressed the main relevance of major depression (OR = 12.82, 95% CI = 2.58-63.76, P= 0.002) and motor impulsivity (OR = 1.21, 95% CI = 1.06-1.38, P= 0.005) to suicide risk. Conclusion: Depression has a major influence on suicidality in epilepsy. Motor impulsivity is also relevant and may be an important component of depression in TLE associated with suicide risk.
KW - Antiepileptic drugs
KW - Depression
KW - Epilepsy
KW - Impulsivity
KW - Suicide
KW - Temporal lobe epilepsy
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U2 - 10.1016/j.yebeh.2011.09.004
DO - 10.1016/j.yebeh.2011.09.004
M3 - Article
C2 - 22018800
AN - SCOPUS:82955232929
SN - 1525-5050
VL - 22
SP - 745
EP - 749
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 4
ER -