Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic; Young H. You; Kumar Sharma

doi:10.1016/j.semnephrol.2012.04.005

Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic
, Young H. You
, Kumar Sharma

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

Original language	English (US)
Pages (from-to)	261-268
Number of pages	8
Journal	Seminars in nephrology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.semnephrol.2012.04.005
State	Published - May 2012
Externally published	Yes

Keywords

Diabetes
Kidney
Sex difference

ASJC Scopus subject areas

Nephrology

Access to Document

10.1016/j.semnephrol.2012.04.005

Cite this

@article{805238db94ff47ea8d36991443c85aad,

title = "Sugar, Sex, and TGF-β in Diabetic Nephropathy",

abstract = "TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.",

keywords = "Diabetes, Kidney, Sex difference",

author = "Diamond-Stanic, \{Maggie K.\} and You, \{Young H.\} and Kumar Sharma",

note = "Funding Information: Financial support: Supported in part by National Institutes of Health ( R01 DK 053867 and U01 DK 060995 ), and a VA Merit Award. ",

year = "2012",

month = may,

doi = "10.1016/j.semnephrol.2012.04.005",

language = "English (US)",

volume = "32",

pages = "261--268",

journal = "Seminars in nephrology",

issn = "0270-9295",

publisher = "W.B. Saunders",

number = "3",

}

TY - JOUR

T1 - Sugar, Sex, and TGF-β in Diabetic Nephropathy

AU - Diamond-Stanic, Maggie K.

AU - You, Young H.

AU - Sharma, Kumar

N1 - Funding Information: Financial support: Supported in part by National Institutes of Health ( R01 DK 053867 and U01 DK 060995 ), and a VA Merit Award.

PY - 2012/5

Y1 - 2012/5

N2 - TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

AB - TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

KW - Diabetes

KW - Kidney

KW - Sex difference

UR - https://www.scopus.com/pages/publications/84864131121

UR - https://www.scopus.com/pages/publications/84864131121#tab=citedBy

U2 - 10.1016/j.semnephrol.2012.04.005

DO - 10.1016/j.semnephrol.2012.04.005

M3 - Article

C2 - 22835457

AN - SCOPUS:84864131121

SN - 0270-9295

VL - 32

SP - 261

EP - 268

JO - Seminars in nephrology

JF - Seminars in nephrology

IS - 3

ER -

Sugar, Sex, and TGF-β in Diabetic Nephropathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this