Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic; Young H. You; Kumar Sharma

doi:10.1016/j.semnephrol.2012.04.005

Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic, Young H. You, Kumar Sharma

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

Original language	English (US)
Pages (from-to)	261-268
Number of pages	8
Journal	Seminars in nephrology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.semnephrol.2012.04.005
State	Published - May 2012
Externally published	Yes

Keywords

Diabetes
Kidney
Sex difference

ASJC Scopus subject areas

Nephrology

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10.1016/j.semnephrol.2012.04.005

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title = "Sugar, Sex, and TGF-β in Diabetic Nephropathy",

abstract = "TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.",

keywords = "Diabetes, Kidney, Sex difference",

author = "Diamond-Stanic, {Maggie K.} and You, {Young H.} and Kumar Sharma",

note = "Funding Information: Financial support: Supported in part by National Institutes of Health ( R01 DK 053867 and U01 DK 060995 ), and a VA Merit Award. ",

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AU - Diamond-Stanic, Maggie K.

AU - You, Young H.

AU - Sharma, Kumar

N1 - Funding Information: Financial support: Supported in part by National Institutes of Health ( R01 DK 053867 and U01 DK 060995 ), and a VA Merit Award.

PY - 2012/5

Y1 - 2012/5

N2 - TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

AB - TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

KW - Diabetes

KW - Kidney

KW - Sex difference

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ER -

Sugar, Sex, and TGF-β in Diabetic Nephropathy

Abstract

Keywords

ASJC Scopus subject areas

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