Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic, Young H. You, Kumar Sharma

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalSeminars in nephrology
Volume32
Issue number3
DOIs
StatePublished - May 1 2012

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Keywords

  • Diabetes
  • Kidney
  • Sex difference

ASJC Scopus subject areas

  • Nephrology

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