@article{da364b51dba540ca80069aa985dd17e9,
title = "Succinate semialdehyde dehydrogenase deficiency does not down-regulate γ-hydroxybutyric acid binding sites in the mouse brain",
abstract = "We investigated whether succinate semialdehyde dehydrogenase deficiency alters γ-hydroxybutyric acid (GHB) receptor characteristics due to elevation of GHB levels in the mouse brain. The membrane homogenate binding and quantitative autoradiography using [3H]NCS-382 revealed no significant changes in the affinity (Kd), receptor density (Bmax), or displacement potency (IC50) in various brain regions of Aldh5a1-/- vs. Aldh5a1+/+ mice.",
keywords = "Autoradiography, GHB receptor, Membrane homogenate binding, SSADH deficiency, [H]NCS-382",
author = "Mehta, {Ashok K.} and Gould, {Georgianna G.} and Maneesh Gupta and Carter, {Lawrence P.} and Gibson, {K. Michael} and Ticku, {Maharaj K.}",
note = "Funding Information: We are grateful to Dr. Julie G. Hensler, Dr. Alan Frazer, and Dr. Charles P. France for their helpful comments and suggestions, and to Ms. Micaella Saldana and Ms. Lei Shi for their expert technical assistance. NCS-382 and [ 3 H]NCS-382 were kindly provided by Dr. Andrew Coop and American Radiolabeled Chemicals (St. Louis, MO, USA), respectively. This work was supported by NIDA Grant #DA14986, NIMH Grant #MH57001, NIH Grant #NS40270 and members of the Partnership for Pediatric Epilepsy Research including the American Epilepsy Society, the Epilepsy Foundation, Anna and Jim Fantaci, Fight Against Childhood Epilepsy and Seizures (FACES), Neurotherapy Ventures Charitable Research Fund, and Parents Against Childhood Epilepsy (PACE). ",
year = "2006",
month = may,
doi = "10.1016/j.ymgme.2005.11.012",
language = "English (US)",
volume = "88",
pages = "86--89",
journal = "Biochemical Medicine and Metabolic Biology",
issn = "1096-7192",
publisher = "Academic Press Inc.",
number = "1",
}