Successful Treatment of Osteosarcoma Without Methotrexate in a 13-Year-Old Boy with Down Syndrome

Emma Sims, Audrey Nath, Aaron Sugalski

Research output: Contribution to journalArticle

Abstract

Osteosarcoma is the most common primary bone tumor in children, and only 1 article in the literature describes a case of osteosarcoma in a patient with Down syndrome. Although osteosarcoma is generally treated with chemotherapy regimens that include high-dose methotrexate, patients with Down syndrome have heightened sensitivity to the toxicities of methotrexate. The patient from the aforementioned case study died from sepsis soon after treatment with high-dose methotrexate. This case report describes the successful treatment of osteosarcoma in a pediatric patient with Down syndrome without methotrexate.

Original languageEnglish (US)
Pages (from-to)71-73
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • methotrexate
  • osteosarcoma
  • trisomy 21

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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