Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

W. C. Wang; J. Cordoba; A. J. Infante; M. E. Conley

Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

W. C. Wang, J. Cordoba, A. J. Infante, M. E. Conley

Research output: Contribution to journal › Article › peer-review

Abstract

Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 10⁹/L to 3.36 x 10⁹/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.

Original language	English (US)
Pages (from-to)	160-163
Number of pages	4
Journal	American Journal of Pediatric Hematology/Oncology
Volume	16
Issue number	2
State	Published - Jan 1 1994
Externally published	Yes

Keywords

Granulocyte colony-stimulating factor
Hyper-immunoglobulin M syndrome
Intravenous gammaglobulin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Cite this

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title = "Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor",

abstract = "Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 109/L to 3.36 x 109/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.",

keywords = "Granulocyte colony-stimulating factor, Hyper-immunoglobulin M syndrome, Intravenous gammaglobulin",

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T1 - Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

AU - Wang, W. C.

AU - Cordoba, J.

AU - Infante, A. J.

AU - Conley, M. E.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 109/L to 3.36 x 109/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.

AB - Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 109/L to 3.36 x 109/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.

KW - Granulocyte colony-stimulating factor

KW - Hyper-immunoglobulin M syndrome

KW - Intravenous gammaglobulin

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Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

Abstract

Keywords

ASJC Scopus subject areas

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