Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

W. C. Wang, J. Cordoba, A. J. Infante, M. E. Conley

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 109/L to 3.36 x 109/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume16
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • Granulocyte colony-stimulating factor
  • Hyper-immunoglobulin M syndrome
  • Intravenous gammaglobulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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