Successful therapy for cerebral phaeohyphomycosis due to dactylaria gallopava in a liver transplant recipient

Rade B. Vukmir; Shimon Kusne; Peter Linden; William Pasculle; Annette W. Fothergill; John Sheaffer; Jose Nieto; Ricardo Segal; Hadar Merhav; A. Julio Martinez; Michael G. Rinaldi

doi:10.1093/clinids/19.4.714

Successful therapy for cerebral phaeohyphomycosis due to dactylaria gallopava in a liver transplant recipient

Rade B. Vukmir, Shimon Kusne, Peter Linden, William Pasculle, Annette W. Fothergill, John Sheaffer, Jose Nieto, Ricardo Segal, Hadar Merhav, A. Julio Martinez, Michael G. Rinaldi

Pathology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A 68-year-old liver transplant recipient who was being treated with FK 506 andimmunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.

Original language	English (US)
Pages (from-to)	714-719
Number of pages	6
Journal	Clinical Infectious Diseases
Volume	19
Issue number	4
DOIs	https://doi.org/10.1093/clinids/19.4.714
State	Published - Oct 1994

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/clinids/19.4.714

Cite this

@article{401209e2c355432e8c981ce90509eb2b,

title = "Successful therapy for cerebral phaeohyphomycosis due to dactylaria gallopava in a liver transplant recipient",

abstract = "A 68-year-old liver transplant recipient who was being treated with FK 506 andimmunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.",

author = "Vukmir, {Rade B.} and Shimon Kusne and Peter Linden and William Pasculle and Fothergill, {Annette W.} and John Sheaffer and Jose Nieto and Ricardo Segal and Hadar Merhav and Martinez, {A. Julio} and Rinaldi, {Michael G.}",

year = "1994",

month = oct,

doi = "10.1093/clinids/19.4.714",

language = "English (US)",

volume = "19",

pages = "714--719",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Successful therapy for cerebral phaeohyphomycosis due to dactylaria gallopava in a liver transplant recipient

AU - Vukmir, Rade B.

AU - Kusne, Shimon

AU - Linden, Peter

AU - Pasculle, William

AU - Fothergill, Annette W.

AU - Sheaffer, John

AU - Nieto, Jose

AU - Segal, Ricardo

AU - Merhav, Hadar

AU - Martinez, A. Julio

AU - Rinaldi, Michael G.

PY - 1994/10

Y1 - 1994/10

N2 - A 68-year-old liver transplant recipient who was being treated with FK 506 andimmunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.

AB - A 68-year-old liver transplant recipient who was being treated with FK 506 andimmunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.

UR - http://www.scopus.com/inward/record.url?scp=0027963159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027963159&partnerID=8YFLogxK

U2 - 10.1093/clinids/19.4.714

DO - 10.1093/clinids/19.4.714

M3 - Article

C2 - 7803637

AN - SCOPUS:0027963159

VL - 19

SP - 714

EP - 719

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 4

ER -

Successful therapy for cerebral phaeohyphomycosis due to dactylaria gallopava in a liver transplant recipient

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this