Successful therapy for cerebral phaeohyphomycosis due to dactylaria gallopava in a liver transplant recipient

Rade B. Vukmir, Shimon Kusne, Peter Linden, William Pasculle, Annette W. Fothergill, John Sheaffer, Jose Nieto, Ricardo Segal, Hadar Merhav, A. Julio Martinez, Michael G. Rinaldi

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A 68-year-old liver transplant recipient who was being treated with FK 506 andimmunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalClinical Infectious Diseases
Volume19
Issue number4
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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