Substrate surface morphology in scaffold design for bone and cartilage tissue engineering

Barbara D. Boyan; Zvi Schwartz

Substrate surface morphology in scaffold design for bone and cartilage tissue engineering

Barbara D. Boyan, Zvi Schwartz

Periodontics

Research output: Contribution to conference › Paper › peer-review

Abstract

The influence of substrate surface morphology in scaffold design for bone and cartilage tissue engineering was investigated. Cells were cultured on Ti disks that were modified to have smooth and rough surface morphologies with specific characteristics. Cell attachment, proliferation, matrix production, differentiation, production of local regulatory factors were assessed. It was observed that the shape of the cell was affected by the topography of the substrate. The cell number was also found to be reduced on rougher surfaces, reflecting not only that there were fewer attached cells initially but also a decrease in the proliferation rate.

Original language	English (US)
Number of pages	1
State	Published - Dec 1 2002
Event	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States Duration: Oct 13 2002 → Oct 16 2002

Other

Other	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country	United States
City	Atlanta, GA
Period	10/13/02 → 10/16/02

ASJC Scopus subject areas

Engineering(all)

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title = "Substrate surface morphology in scaffold design for bone and cartilage tissue engineering",

abstract = "The influence of substrate surface morphology in scaffold design for bone and cartilage tissue engineering was investigated. Cells were cultured on Ti disks that were modified to have smooth and rough surface morphologies with specific characteristics. Cell attachment, proliferation, matrix production, differentiation, production of local regulatory factors were assessed. It was observed that the shape of the cell was affected by the topography of the substrate. The cell number was also found to be reduced on rougher surfaces, reflecting not only that there were fewer attached cells initially but also a decrease in the proliferation rate.",

author = "Boyan, {Barbara D.} and Zvi Schwartz",

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AU - Schwartz, Zvi

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N2 - The influence of substrate surface morphology in scaffold design for bone and cartilage tissue engineering was investigated. Cells were cultured on Ti disks that were modified to have smooth and rough surface morphologies with specific characteristics. Cell attachment, proliferation, matrix production, differentiation, production of local regulatory factors were assessed. It was observed that the shape of the cell was affected by the topography of the substrate. The cell number was also found to be reduced on rougher surfaces, reflecting not only that there were fewer attached cells initially but also a decrease in the proliferation rate.

AB - The influence of substrate surface morphology in scaffold design for bone and cartilage tissue engineering was investigated. Cells were cultured on Ti disks that were modified to have smooth and rough surface morphologies with specific characteristics. Cell attachment, proliferation, matrix production, differentiation, production of local regulatory factors were assessed. It was observed that the shape of the cell was affected by the topography of the substrate. The cell number was also found to be reduced on rougher surfaces, reflecting not only that there were fewer attached cells initially but also a decrease in the proliferation rate.

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