Substrate surface morphology in scaffold design for bone and cartilage tissue engineering

Barbara D. Boyan, Zvi Schwartz

Research output: Contribution to conferencePaper

Abstract

The influence of substrate surface morphology in scaffold design for bone and cartilage tissue engineering was investigated. Cells were cultured on Ti disks that were modified to have smooth and rough surface morphologies with specific characteristics. Cell attachment, proliferation, matrix production, differentiation, production of local regulatory factors were assessed. It was observed that the shape of the cell was affected by the topography of the substrate. The cell number was also found to be reduced on rougher surfaces, reflecting not only that there were fewer attached cells initially but also a decrease in the proliferation rate.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 2002
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: Oct 13 2002Oct 16 2002

Other

OtherThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
CountryUnited States
CityAtlanta, GA
Period10/13/0210/16/02

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Boyan, B. D., & Schwartz, Z. (2002). Substrate surface morphology in scaffold design for bone and cartilage tissue engineering. Paper presented at Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, Atlanta, GA, United States.