Sublethal Cytotoxic Effects of Mercuric Chloride on the Ciliate Tetrahymena pyriformis

LESLIE E. TINGLE, WILLIAM A. PAVLAT, IVAN L. CAMERON

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

SYNOPSIS. The behavior and ultrastructure of Tetrahymena pyriformis was assessed after exposure to dosages of 8 and 16% of the lethal concentration of HgCl2 (TLm 96 hr). The lower dosage caused no abnormal changes in cell motility, activity of the water explusion vesicles, or cell shape; the higher dosage caused deleterious changes in these parameters. The higher sublethal HgCl2 concentration (0.50 mg/liter) elicited damage of several cell structures. This damage persisted and accumulated with time up to 24 hr. At the lower HgCl2 dosage (0.25 mg liter) there were extensive changes after 1‐hr exposure involving primarily mitochondria; however, all major changes were repaired after 24 hr of constant exposure to the HgCl2, indicating adaptation to the toxicant. Based solely on cytotoxic evidence an attempt is made to apply the findings defining what constitutes a “safe'’concentration of HgCl2 in the cell's environment.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalThe Journal of Protozoology
Volume20
Issue number2
DOIs
StatePublished - May 1973
Externally publishedYes

Keywords

  • cytotoxicity of
  • electron microscopy
  • HgClz
  • light microscopy
  • Tetrahymena pyriformis strain HSM

ASJC Scopus subject areas

  • Parasitology

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