Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study

Marsal Sanches; Roberto B. Sassi; David Axelson; Mark Nicoletti; Paolo Brambilla; John P. Hatch; Matcheri S. Keshavan; Neal D. Ryan; Boris Birmaher; Jair C. Soares

doi:10.1016/j.pscychresns.2004.11.004

Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study

Marsal Sanches, Roberto B. Sassi, David Axelson, Mark Nicoletti, Paolo Brambilla, John P. Hatch, Matcheri S. Keshavan, Neal D. Ryan, Boris Birmaher, Jair C. Soares

Department of Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria for bipolar disorder (mean age±S.D.=15.5±3.5 years) and 21 healthy adolescents (mean age±S.D.=16.9±3.8 years). MR images were obtained with a 1.5 T GE Signa Imaging System with Signa 5.4.3 software. SGPFC volumes were measured with the semi-automated software MedX (Sensor Systems, Sterling, VA, USA). ANCOVA was performed to compare SGPFC volumes between groups, using age, gender and intra-cranial volume (ICV) as covariates. The volumes (mean±S.D.) of the right and left SGPFC for bipolar patients were 291.27±88.70 mm³ and 284.86±83.98 mm³, respectively. For healthy controls, the right and left SGPFC volumes were 284.95±73.33 mm³ and 307.55±73.67 mm ³, respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Psychiatry Research - Neuroimaging
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.pscychresns.2004.11.004
State	Published - Jan 30 2005

Keywords

Adolescents
Bipolar disorder
Neuroimaging
Prefrontal cortex

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2004.11.004

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Sanches, M., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Hatch, J. P., Keshavan, M. S., Ryan, N. D., Birmaher, B., & Soares, J. C. (2005). Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study. Psychiatry Research - Neuroimaging, 138(1), 43-49. https://doi.org/10.1016/j.pscychresns.2004.11.004

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title = "Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study",

abstract = "The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria for bipolar disorder (mean age±S.D.=15.5±3.5 years) and 21 healthy adolescents (mean age±S.D.=16.9±3.8 years). MR images were obtained with a 1.5 T GE Signa Imaging System with Signa 5.4.3 software. SGPFC volumes were measured with the semi-automated software MedX (Sensor Systems, Sterling, VA, USA). ANCOVA was performed to compare SGPFC volumes between groups, using age, gender and intra-cranial volume (ICV) as covariates. The volumes (mean±S.D.) of the right and left SGPFC for bipolar patients were 291.27±88.70 mm3 and 284.86±83.98 mm3, respectively. For healthy controls, the right and left SGPFC volumes were 284.95±73.33 mm3 and 307.55±73.67 mm 3, respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents.",

keywords = "Adolescents, Bipolar disorder, Neuroimaging, Prefrontal cortex",

author = "Marsal Sanches and Sassi, {Roberto B.} and David Axelson and Mark Nicoletti and Paolo Brambilla and Hatch, {John P.} and Keshavan, {Matcheri S.} and Ryan, {Neal D.} and Boris Birmaher and Soares, {Jair C.}",

note = "Funding Information: This work was partly supported by grants MH 01736, MH 55123, MH 30915 and MH 59929 from the National Institute of Mental Health, NARSAD, the Krus Endowed Chair in Psychiatry (The University of Texas Health Science Center at San Antonio) and CAPES Foundation (Brazil).",

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doi = "10.1016/j.pscychresns.2004.11.004",

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AU - Sanches, Marsal

AU - Sassi, Roberto B.

AU - Axelson, David

AU - Nicoletti, Mark

AU - Brambilla, Paolo

AU - Hatch, John P.

AU - Keshavan, Matcheri S.

AU - Ryan, Neal D.

AU - Birmaher, Boris

AU - Soares, Jair C.

N1 - Funding Information: This work was partly supported by grants MH 01736, MH 55123, MH 30915 and MH 59929 from the National Institute of Mental Health, NARSAD, the Krus Endowed Chair in Psychiatry (The University of Texas Health Science Center at San Antonio) and CAPES Foundation (Brazil).

PY - 2005/1/30

Y1 - 2005/1/30

N2 - The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria for bipolar disorder (mean age±S.D.=15.5±3.5 years) and 21 healthy adolescents (mean age±S.D.=16.9±3.8 years). MR images were obtained with a 1.5 T GE Signa Imaging System with Signa 5.4.3 software. SGPFC volumes were measured with the semi-automated software MedX (Sensor Systems, Sterling, VA, USA). ANCOVA was performed to compare SGPFC volumes between groups, using age, gender and intra-cranial volume (ICV) as covariates. The volumes (mean±S.D.) of the right and left SGPFC for bipolar patients were 291.27±88.70 mm3 and 284.86±83.98 mm3, respectively. For healthy controls, the right and left SGPFC volumes were 284.95±73.33 mm3 and 307.55±73.67 mm 3, respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents.

AB - The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria for bipolar disorder (mean age±S.D.=15.5±3.5 years) and 21 healthy adolescents (mean age±S.D.=16.9±3.8 years). MR images were obtained with a 1.5 T GE Signa Imaging System with Signa 5.4.3 software. SGPFC volumes were measured with the semi-automated software MedX (Sensor Systems, Sterling, VA, USA). ANCOVA was performed to compare SGPFC volumes between groups, using age, gender and intra-cranial volume (ICV) as covariates. The volumes (mean±S.D.) of the right and left SGPFC for bipolar patients were 291.27±88.70 mm3 and 284.86±83.98 mm3, respectively. For healthy controls, the right and left SGPFC volumes were 284.95±73.33 mm3 and 307.55±73.67 mm 3, respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents.

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KW - Neuroimaging

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Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study

Abstract

Keywords

ASJC Scopus subject areas

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