In a reproducible infected rat burn model, subeschar infusion of antibiotics failed to protect the animals from death via bum wound invasion excepting those animals receiving carbenicillin. Subcutaneous injection of maximal doses of carbenicillin at a distance from the bum wound protected these animals equally well. Some advantage was defined for the subeschar route of administration with suboptimal doses of carbenicillin. More important is the fact that prospective selection of an effective antibiotic could not be made on the basis of in vitro antibiotic sensitivity tests.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Trauma - Injury, Infection and Critical Care|
|State||Published - Dec 1980|
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine