Subdural electrode recording of generalized photoepileptic responses

L. Mukundan, Octavian Lie, Linda D Leary, Alexander M Papanastassiou, Lola Morgan, Charles A Szabo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We evaluated the spatiotemporal distribution of photic driving (PDR), photoparoxysmal (PPR), and photoconvulsive (PCR) responses recorded by intracranial electrodes (ic-EEG) in a patient with generalized photosensitivity and right frontal lobe cortical dysplasia. Intermittent light stimulation (ILS) was performed thirteen times in nine days. Cortical responses to ILS recorded by ic-EEG were reviewed and classified as PDRs, PPRs, and PCRs. Photic driving responses were restricted to the occipital lobe at ILS frequencies below 9. Hz, spreading to the parietal and central regions at >. 9. Hz. Photoparoxysmal responses commonly presented as focal, medial occipital, and parietal interictal epileptic discharges (IEDs), the latter propagating to the sensorimotor cortices. Generalized IEDs were also generated in the setting of PPRs. Photoconvulsive responses, characterized by repetitive bilateral upper extremity myoclonus sustained until the end of the stimulus, were associated with propagation of the medial parieto-occipital discharge to the primary sensorimotor and supplementary area cortices, while generalized myoclonic seizures were associated with a generalized spike-and-wave discharge with an interhemispheric posterior cingulate onset sparing the sensorimotor cortices. Both types of PCR could occur during the same stimulus. Regardless of the pathway, PCRs only occurred when PDRs involved the parietal cortices. While there may be more than one pathway underlying PCRs, parietal lobe association cortices appear to be critical to their generation.

Original languageEnglish (US)
Pages (from-to)4-7
Number of pages4
JournalEpilepsy and Behavior Case Reports
Volume3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Electrodes
Parietal Lobe
Polymerase Chain Reaction
Light
Electroencephalography
Malformations of Cortical Development
Occipital Lobe
Myoclonus
Gyrus Cinguli
Frontal Lobe
Seizures
Sensorimotor Cortex

Keywords

  • Cortical dysplasia
  • Epilepsy surgery
  • Generalized photoconvulsive response
  • Intracranial EEG
  • Photosensitivity

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neurology
  • Clinical Neurology

Cite this

Subdural electrode recording of generalized photoepileptic responses. / Mukundan, L.; Lie, Octavian; Leary, Linda D; Papanastassiou, Alexander M; Morgan, Lola; Szabo, Charles A.

In: Epilepsy and Behavior Case Reports, Vol. 3, 01.01.2015, p. 4-7.

Research output: Contribution to journalArticle

Mukundan, L. ; Lie, Octavian ; Leary, Linda D ; Papanastassiou, Alexander M ; Morgan, Lola ; Szabo, Charles A. / Subdural electrode recording of generalized photoepileptic responses. In: Epilepsy and Behavior Case Reports. 2015 ; Vol. 3. pp. 4-7.
@article{ba567998059e4bab80a6fd6fa20eb43f,
title = "Subdural electrode recording of generalized photoepileptic responses",
abstract = "We evaluated the spatiotemporal distribution of photic driving (PDR), photoparoxysmal (PPR), and photoconvulsive (PCR) responses recorded by intracranial electrodes (ic-EEG) in a patient with generalized photosensitivity and right frontal lobe cortical dysplasia. Intermittent light stimulation (ILS) was performed thirteen times in nine days. Cortical responses to ILS recorded by ic-EEG were reviewed and classified as PDRs, PPRs, and PCRs. Photic driving responses were restricted to the occipital lobe at ILS frequencies below 9. Hz, spreading to the parietal and central regions at >. 9. Hz. Photoparoxysmal responses commonly presented as focal, medial occipital, and parietal interictal epileptic discharges (IEDs), the latter propagating to the sensorimotor cortices. Generalized IEDs were also generated in the setting of PPRs. Photoconvulsive responses, characterized by repetitive bilateral upper extremity myoclonus sustained until the end of the stimulus, were associated with propagation of the medial parieto-occipital discharge to the primary sensorimotor and supplementary area cortices, while generalized myoclonic seizures were associated with a generalized spike-and-wave discharge with an interhemispheric posterior cingulate onset sparing the sensorimotor cortices. Both types of PCR could occur during the same stimulus. Regardless of the pathway, PCRs only occurred when PDRs involved the parietal cortices. While there may be more than one pathway underlying PCRs, parietal lobe association cortices appear to be critical to their generation.",
keywords = "Cortical dysplasia, Epilepsy surgery, Generalized photoconvulsive response, Intracranial EEG, Photosensitivity",
author = "L. Mukundan and Octavian Lie and Leary, {Linda D} and Papanastassiou, {Alexander M} and Lola Morgan and Szabo, {Charles A}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.ebcr.2014.10.002",
language = "English (US)",
volume = "3",
pages = "4--7",
journal = "Epilepsy and Behavior Case Reports",
issn = "2213-3232",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Subdural electrode recording of generalized photoepileptic responses

AU - Mukundan, L.

AU - Lie, Octavian

AU - Leary, Linda D

AU - Papanastassiou, Alexander M

AU - Morgan, Lola

AU - Szabo, Charles A

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We evaluated the spatiotemporal distribution of photic driving (PDR), photoparoxysmal (PPR), and photoconvulsive (PCR) responses recorded by intracranial electrodes (ic-EEG) in a patient with generalized photosensitivity and right frontal lobe cortical dysplasia. Intermittent light stimulation (ILS) was performed thirteen times in nine days. Cortical responses to ILS recorded by ic-EEG were reviewed and classified as PDRs, PPRs, and PCRs. Photic driving responses were restricted to the occipital lobe at ILS frequencies below 9. Hz, spreading to the parietal and central regions at >. 9. Hz. Photoparoxysmal responses commonly presented as focal, medial occipital, and parietal interictal epileptic discharges (IEDs), the latter propagating to the sensorimotor cortices. Generalized IEDs were also generated in the setting of PPRs. Photoconvulsive responses, characterized by repetitive bilateral upper extremity myoclonus sustained until the end of the stimulus, were associated with propagation of the medial parieto-occipital discharge to the primary sensorimotor and supplementary area cortices, while generalized myoclonic seizures were associated with a generalized spike-and-wave discharge with an interhemispheric posterior cingulate onset sparing the sensorimotor cortices. Both types of PCR could occur during the same stimulus. Regardless of the pathway, PCRs only occurred when PDRs involved the parietal cortices. While there may be more than one pathway underlying PCRs, parietal lobe association cortices appear to be critical to their generation.

AB - We evaluated the spatiotemporal distribution of photic driving (PDR), photoparoxysmal (PPR), and photoconvulsive (PCR) responses recorded by intracranial electrodes (ic-EEG) in a patient with generalized photosensitivity and right frontal lobe cortical dysplasia. Intermittent light stimulation (ILS) was performed thirteen times in nine days. Cortical responses to ILS recorded by ic-EEG were reviewed and classified as PDRs, PPRs, and PCRs. Photic driving responses were restricted to the occipital lobe at ILS frequencies below 9. Hz, spreading to the parietal and central regions at >. 9. Hz. Photoparoxysmal responses commonly presented as focal, medial occipital, and parietal interictal epileptic discharges (IEDs), the latter propagating to the sensorimotor cortices. Generalized IEDs were also generated in the setting of PPRs. Photoconvulsive responses, characterized by repetitive bilateral upper extremity myoclonus sustained until the end of the stimulus, were associated with propagation of the medial parieto-occipital discharge to the primary sensorimotor and supplementary area cortices, while generalized myoclonic seizures were associated with a generalized spike-and-wave discharge with an interhemispheric posterior cingulate onset sparing the sensorimotor cortices. Both types of PCR could occur during the same stimulus. Regardless of the pathway, PCRs only occurred when PDRs involved the parietal cortices. While there may be more than one pathway underlying PCRs, parietal lobe association cortices appear to be critical to their generation.

KW - Cortical dysplasia

KW - Epilepsy surgery

KW - Generalized photoconvulsive response

KW - Intracranial EEG

KW - Photosensitivity

UR - http://www.scopus.com/inward/record.url?scp=84920140003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920140003&partnerID=8YFLogxK

U2 - 10.1016/j.ebcr.2014.10.002

DO - 10.1016/j.ebcr.2014.10.002

M3 - Article

AN - SCOPUS:84920140003

VL - 3

SP - 4

EP - 7

JO - Epilepsy and Behavior Case Reports

JF - Epilepsy and Behavior Case Reports

SN - 2213-3232

ER -