Subcutaneous melatonin implants inhibit reproductive atrophy in Male hamsters induced by daily melatonin injections

Russel J. Reiter, P. Kevin Rudeen, Jeffrey W. Sackman, Mary K. Vaughan, Linda Y. Johnson, John C. Little

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Daily afternoon (at 7 p.m.) injections of melatonin (25 μg in oil) into adult male hamsters for 50 days led to atrophy of the testes and accessory sex organs (seminal vesicles and coagulating glands) and in a significant depression in pituitary LH and prolactin content and concentration. These actions of melatonin were prevented if the animals had been pinealectomized before the daily melatonin injections were begun. Likewise, if hamsters received a weekly subcutaneous implant of melatonin in beeswax (1 mg melatonin in 24 mg beeswax) the daily melatonin injections failed to inhibit the growth of the reproductive organs and to depress pituitary LH and prolactin levels. Beeswax by itself had no such effect.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalEndocrine Research
Volume4
Issue number1
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Endocrinology

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