Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome

David H. Malin, J. Ronald Lake, K'Anne R. Arcangeli, Karen D. Deshotel, David D. Hausam, Wendi E. Witherspoon, Victoria A. Carter, Hsiu Ying T. Yang, Biman Pal, Kevin Burgess

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats, but not in sham controls.

Original languageEnglish (US)
Pages (from-to)PL261-PL266
JournalLife Sciences
Volume53
Issue number17
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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