Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome

David H. Malin, J. Ronald Lake, K'Anne R. Arcangeli, Karen D. Deshotel, David D. Hausam, Wendi E. Witherspoon, Victoria A. Carter, Hsiu Ying T Yang, Biman Pal, Kevin Burgess

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats, but not in sham controls.

Original languageEnglish (US)
JournalLife Sciences
Volume53
Issue number17
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Opiate Alkaloids
Subcutaneous Injections
Morphine
Rats
Precipitates
Third Ventricle
Ethanol
Injections
Water
phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide

ASJC Scopus subject areas

  • Pharmacology

Cite this

Malin, D. H., Ronald Lake, J., Arcangeli, KA. R., Deshotel, K. D., Hausam, D. D., Witherspoon, W. E., ... Burgess, K. (1993). Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome. Life Sciences, 53(17). https://doi.org/10.1016/0024-3205(93)90601-X

Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome. / Malin, David H.; Ronald Lake, J.; Arcangeli, K'Anne R.; Deshotel, Karen D.; Hausam, David D.; Witherspoon, Wendi E.; Carter, Victoria A.; Yang, Hsiu Ying T; Pal, Biman; Burgess, Kevin.

In: Life Sciences, Vol. 53, No. 17, 1993.

Research output: Contribution to journalArticle

Malin, DH, Ronald Lake, J, Arcangeli, KAR, Deshotel, KD, Hausam, DD, Witherspoon, WE, Carter, VA, Yang, HYT, Pal, B & Burgess, K 1993, 'Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome', Life Sciences, vol. 53, no. 17. https://doi.org/10.1016/0024-3205(93)90601-X
Malin DH, Ronald Lake J, Arcangeli KAR, Deshotel KD, Hausam DD, Witherspoon WE et al. Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome. Life Sciences. 1993;53(17). https://doi.org/10.1016/0024-3205(93)90601-X
Malin, David H. ; Ronald Lake, J. ; Arcangeli, K'Anne R. ; Deshotel, Karen D. ; Hausam, David D. ; Witherspoon, Wendi E. ; Carter, Victoria A. ; Yang, Hsiu Ying T ; Pal, Biman ; Burgess, Kevin. / Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome. In: Life Sciences. 1993 ; Vol. 53, No. 17.
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