Subcutaneous calcium deposition in the neonate associated with intravenous administration of calcium gluconate.

R. S. Ramamurthy, V. Harris, R. S. Pildes

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27 Scopus citations


Nine infants who had severe local manifestations following intravenous administration of calcium gluconate are presented. The lesions appeared at the intravenous sites as firm subcutaneous nodules or areas of areas of inflammation with central softening and fluctuation. The interval between appearance of the lesion and calcium administration was 13 plus or minus 2.5 (mean plus or minus SEM) days. Five infants were treated with antibiotics and three of the five had incision and drainage. Roentgenographic evidence of subcutaneous calcification was seen in all cases at the time the lesions were first noticed. In two infants the entire cephalic vein was calcified. Induration and inflammation completely subsided in six infants, four of whom had follow-up roentgenograms showing complete resolution of calcification. A conservative approach in management is recommended.

Original languageEnglish (US)
Pages (from-to)802-806
Number of pages5
Issue number6
StatePublished - Jun 1 1975


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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