Studying the Dopaminergic System with Transfected Receptors

Ikuyo Yamaguchi; Scott F. Walk; Robin A. Felder

doi:10.1291/hypres.18.SupplementI_S19

Studying the Dopaminergic System with Transfected Receptors

Ikuyo Yamaguchi, Scott F. Walk, Robin A. Felder

Research output: Contribution to journal › Article › peer-review

Abstract

Dopamine receptors are responsible for diverse effects within and outside the central nervous system. The five dopamine receptors that have been cloned (D_1A, D_1B also known as D₅, D₂, D₃, and D₄) belong to two major families; the D₁ like and D₂ like dopamine receptors. The D₁ like receptors are linked to the stimulation while D₂ like receptors are linked to the inhibition of adenylyl cyclase. The physiologic role of the dopamine receptors has been difficult to decipher because several of the subtypes co-exist in the same tissue. However, studies of receptors artificially expressed using transfected cDNA have revealed some of the biochemical mechanisms unique to each dopamine receptor subtype.

Original language	English (US)
Journal	Hypertension Research
Volume	18
DOIs	https://doi.org/10.1291/hypres.18.SupplementI_S19
State	Published - 1995
Externally published	Yes

Keywords

dopamine receptor
receptor synergism
transfected cell

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1291/hypres.18.SupplementI_S19

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abstract = "Dopamine receptors are responsible for diverse effects within and outside the central nervous system. The five dopamine receptors that have been cloned (D1A, D1B also known as D5, D2, D3, and D4) belong to two major families; the D1 like and D2 like dopamine receptors. The D1 like receptors are linked to the stimulation while D2 like receptors are linked to the inhibition of adenylyl cyclase. The physiologic role of the dopamine receptors has been difficult to decipher because several of the subtypes co-exist in the same tissue. However, studies of receptors artificially expressed using transfected cDNA have revealed some of the biochemical mechanisms unique to each dopamine receptor subtype.",

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AU - Walk, Scott F.

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AB - Dopamine receptors are responsible for diverse effects within and outside the central nervous system. The five dopamine receptors that have been cloned (D1A, D1B also known as D5, D2, D3, and D4) belong to two major families; the D1 like and D2 like dopamine receptors. The D1 like receptors are linked to the stimulation while D2 like receptors are linked to the inhibition of adenylyl cyclase. The physiologic role of the dopamine receptors has been difficult to decipher because several of the subtypes co-exist in the same tissue. However, studies of receptors artificially expressed using transfected cDNA have revealed some of the biochemical mechanisms unique to each dopamine receptor subtype.

KW - dopamine receptor

KW - receptor synergism

KW - transfected cell

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Studying the Dopaminergic System with Transfected Receptors

Abstract

Keywords

ASJC Scopus subject areas

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