Study of upper extremity growth and development using human embryos and computer-reconstructed models

Alan E. Seyfer, Gary Wind, Richard R. Martin

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This study investigated the apical ectodermal ridge and early vasculature of the human limb bud by use of histologic techniques and a new method of computer modeling. Fourteen human embryos were studied (more than 10,000 sections) microscopically and the embryonic limbs were reconstructed three-dimensionally by use of a serialized programming method. The apical ectodermal ridge consists of an extensive band of specialized cells, located over the rim of the limb surmounting a strip of rapidly-dividing mesenchymal cells. It is consistently supplied by a large vessel that shows extensive central branching.

Original languageEnglish (US)
Pages (from-to)927-932
Number of pages6
JournalJournal of Hand Surgery
Volume14
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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