Estudio del componente genético de fenotipos de riesgo cardiovascular en población mexicana

Translated title of the contribution: Study of the genetic component of cardiovascular risk phenotypes in a Mexican population

Raúl A. Bastarrachea, Jack Kent, Anthony G. Comuzzie

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h 2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD risk factor phenotypes are estimated using a variance component approach. SUBJECTS AND METHOD: As a first step in implementing a large, multi-center collaborative study, we recruited 381 individuals in 21 families at 8 regions across Mexico. Anthropometric and fasting blood samples were collected from all participants. We estimated the magnitude of the random effects of shared genes (heritability) using the genetic software SOLAR. RESULTS: We found significant heritability for phenotypes including waist circumference (0.28 [0.12]), plasma glucose (0.14 [0.08]), body mass index (BMI) (0.28 [0.10]), systolic bood pressure (BP) (0.13 [0.06]), serum cholesterol (0.31 [0.13]) and serum triglyceride (0.23 [0.10]). CONCLUSIONS: These preliminary data represent the first heritability estimates for these phenotypes in Mexico. The results indicate that this study design offers excellent power for gene discovery relative to metabolic disease.

Translated title of the contributionStudy of the genetic component of cardiovascular risk phenotypes in a Mexican population
Original languageSpanish
Pages (from-to)11-13
Number of pages3
JournalMedicina Clinica
Volume129
Issue number1
DOIs
StatePublished - Jun 2 2007
Externally publishedYes

Keywords

  • Genetic susceptibility
  • Heritability
  • Mexico
  • Variance component

ASJC Scopus subject areas

  • Medicine(all)

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