Studies on the minimal dosage of melatonin required to inhibit pineal antigonadotrophic activity in male golden hamsters

Russel J. Reirer, Mary K. Vaughan, Patricia J. Waring

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Blinding adult male golden hamsters was followed by atrophy, within 12 weeks, of the testes and accessory sex organs (seminal vesicles and coagulating glands) and by a significant reduction in pituitary prolactin levels. In experiment 1 blind hamsters received subcutaneously implanted melatonin-beeswax (1:24 mg) pellets at the following intervals: Once per week, per 2, 3, 4, 6 weeks, or only one pellet during the 12-week experimental period. The melatonin-beeswax pellets, regardless of the frequency of implantation, overcame completely the inhibitory effects of blinding on reproduction and nearly completely the depressant action of light deprivation on pituitary prolactin levels. In the second study the melatonin-beeswax pellets were implanted subcutaneously into blind hamsters every 2 weeks. The pellets contained either 1 μg, 500. 100, 50, or 1 μg melatonin. With the exception of the l-μg dosage, melatonin again negated almost totally the inhibitory action of darkness on the gonads and accessory organs and also, for the most part, prevented the drop in pituitary prolactin levels. Based on these studies, when melatonin is chronically administered subcutaneously in a beeswax pellet the minimal dosage of melatonin required to counteract the inhibitory effect of darkness on reproduction seems to be less than 3.6 jig/day. The effects of chronic melatonin treatment are similar to those of pinealectomy.

Original languageEnglish (US)
Pages (from-to)258-267
Number of pages10
JournalHormone Research in Paediatrics
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1975

Keywords

  • Blinding
  • Hamster
  • Melatonin
  • Pineal gland
  • Prolactin
  • Reproduction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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