Studies on the mechanism(s) of resistance to coxsackie virus B3 (CVB3)-induced myocarditis at adolescence in mice vaccinated at birth with a temperature-sensitive mutant of CVB3

E. K. Godeny, R. S. Cassling, C. J. Gauntt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Vaccination of murine CD-1 neonates with a temperature-sensitive mutant (ts1) virus derived from a coxsackie virus B3 (CVB3(m)) myocarditic parent virus induces resistance in ts1 survivor adolescents to CVB3(m) induction of myocarditis. A highly sensitive assay for anti-CVB3 neutralizing antibody was used to demonstrate antibody in ts1 survivors (seven out of eight) prior to CVB3(m) challenge. This antibody probably accounts for the extremely low CVB3(m) titres found in heart tissues after CVB3(m) challenge, and provides an explanation for the lack of induction of interferon and activation of natural killer cells in CVB3(m)-inoculated ts1 survivors. T suppressor cells may also play a role in resistance of ts1 survivors to CVB3(m)-induced myocarditis, as low-dose cyclophosphamide treatment prior to challenge results in CVB3(m) induction of myocarditis.

Original languageEnglish (US)
Pages (from-to)403-405
Number of pages3
JournalEuropean Heart Journal
Volume8
Issue numberSUPPL. J
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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