Studies on increased vascular permeability in the pathogenesis of lesions of connective tissue disease: I. Experimental hyperlipidaemia and immune arthropathy

A. J. Valente, K. W. Walton

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In order to investigate the known associations between hyperlipaemia and various rheumatic complaints, immune arthritis and hyperlipidaemia have been induced concurrently in rabbits. The results obtained show that: (1) Rabbits apoliprotein B-containing lipoproteins (LpB), which are normally virtually excluded from joint fluid, gain access to the inflamed joint in the serous effusion and serve as intrinsic indicators of altered local permeability to macromolecules. Much of the LpB entering the joint space is taken up by the phagocytic cells and, following intracellular hydrolysis, leaves a lipid residue. In some chronically affected joints these residues are modified so as to give rise to crystalline cholesterol and its esters. Such crystals may serve as a chronic irritant in the joint. In addition intact LpB is found sequestered in the superficial layers of intra-articular collagenous structures of the challenged joint in a distribution identical with that of similarly sequestered immune complexes and complement, suggesting altered permeability of these intra-articular structures also.

Original languageEnglish (US)
Pages (from-to)490-499
Number of pages10
JournalAnnals of the Rheumatic Diseases
Volume39
Issue number5
StatePublished - 1980
Externally publishedYes

Fingerprint

Connective Tissue Diseases
Joint Diseases
Cholesterol Esters
Irritants
Capillary Permeability
Hyperlipidemias
Antigen-Antibody Complex
Macromolecules
Lipoproteins
Hydrolysis
Joints
Tissue
Crystalline materials
Lipids
Crystals
Fluids
Permeability
Rabbits
Phagocytes
Arthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

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abstract = "In order to investigate the known associations between hyperlipaemia and various rheumatic complaints, immune arthritis and hyperlipidaemia have been induced concurrently in rabbits. The results obtained show that: (1) Rabbits apoliprotein B-containing lipoproteins (LpB), which are normally virtually excluded from joint fluid, gain access to the inflamed joint in the serous effusion and serve as intrinsic indicators of altered local permeability to macromolecules. Much of the LpB entering the joint space is taken up by the phagocytic cells and, following intracellular hydrolysis, leaves a lipid residue. In some chronically affected joints these residues are modified so as to give rise to crystalline cholesterol and its esters. Such crystals may serve as a chronic irritant in the joint. In addition intact LpB is found sequestered in the superficial layers of intra-articular collagenous structures of the challenged joint in a distribution identical with that of similarly sequestered immune complexes and complement, suggesting altered permeability of these intra-articular structures also.",
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AU - Walton, K. W.

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N2 - In order to investigate the known associations between hyperlipaemia and various rheumatic complaints, immune arthritis and hyperlipidaemia have been induced concurrently in rabbits. The results obtained show that: (1) Rabbits apoliprotein B-containing lipoproteins (LpB), which are normally virtually excluded from joint fluid, gain access to the inflamed joint in the serous effusion and serve as intrinsic indicators of altered local permeability to macromolecules. Much of the LpB entering the joint space is taken up by the phagocytic cells and, following intracellular hydrolysis, leaves a lipid residue. In some chronically affected joints these residues are modified so as to give rise to crystalline cholesterol and its esters. Such crystals may serve as a chronic irritant in the joint. In addition intact LpB is found sequestered in the superficial layers of intra-articular collagenous structures of the challenged joint in a distribution identical with that of similarly sequestered immune complexes and complement, suggesting altered permeability of these intra-articular structures also.

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