Studies of immune responses in mice prone to autoimmune disorders. II. Decreased down-regulation by auto-anti-idiotype antibody in autoimmune-prone mice

Edmond A. Goidl, Robert A. Good, Gregory W. Siskind, Marc E. Weksler, Gabriel Fernandes

Research output: Contribution to journalArticle

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Abstract

Three lines of evidence are presented which suggest that autoimmune-prone mice are deficient in the production of auto-anti-idiotype antibody during their immune response to trinitrophenylated Ficoll (TNP-F). (1) NZB, MRL lpr/lpr and older BXSB male mice have no hapten-augmentable plaque-forming cells (PFC). Hapten-augmentable PFC have been previously shown to be cells whose secretion of antibody has been inhibited by the binding of auto-anti-idiotype antibody to cell surface idiotype. (2) Sera from TNP-F immunized NZB mice lack PFC inhibiting activity (anti-idiotype antibody). (3) Spleen cells from TNP-F immune NZB mice fail to transfer antiidiotype antibody-mediated suppression to naive mice as do spleen cells from immune nonautoimmune-prone mice. Taken together these data suggest that autoimmune-prone mice are deficient in auto-anti-idiotype antibody-mediated downward regulation of their immune responses. It was further shown that the immune response of NZB mice to TNP-F shows a slower decline in splenic PFC and a greater heterogeneity of PFC affinity than do the responses of non-autoimmune-prone strains. Since athymic (nude) mice, which were previously shown to be defective in the production of auto-anti-idiotype antibody, also show a slower decline in splenic PFC and an increased heterogeneity of PFC affinity, it is suggested that these peculiarities of the immune responses of autoimmune-prone and athymic mice are also the consequences of the lack of autoanti-idiotype antibody-mediated down-regulation.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalCellular Immunology
Volume101
Issue number2
DOIs
StatePublished - 1986

Fingerprint

Anti-Idiotypic Antibodies
Down-Regulation
Ficoll
Inbred NZB Mouse
Nude Mice
Haptens
Autoimmunity
Antibodies
Spleen
Serum

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Studies of immune responses in mice prone to autoimmune disorders. II. Decreased down-regulation by auto-anti-idiotype antibody in autoimmune-prone mice. / Goidl, Edmond A.; Good, Robert A.; Siskind, Gregory W.; Weksler, Marc E.; Fernandes, Gabriel.

In: Cellular Immunology, Vol. 101, No. 2, 1986, p. 281-289.

Research output: Contribution to journalArticle

Goidl, Edmond A. ; Good, Robert A. ; Siskind, Gregory W. ; Weksler, Marc E. ; Fernandes, Gabriel. / Studies of immune responses in mice prone to autoimmune disorders. II. Decreased down-regulation by auto-anti-idiotype antibody in autoimmune-prone mice. In: Cellular Immunology. 1986 ; Vol. 101, No. 2. pp. 281-289.
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abstract = "Three lines of evidence are presented which suggest that autoimmune-prone mice are deficient in the production of auto-anti-idiotype antibody during their immune response to trinitrophenylated Ficoll (TNP-F). (1) NZB, MRL lpr/lpr and older BXSB male mice have no hapten-augmentable plaque-forming cells (PFC). Hapten-augmentable PFC have been previously shown to be cells whose secretion of antibody has been inhibited by the binding of auto-anti-idiotype antibody to cell surface idiotype. (2) Sera from TNP-F immunized NZB mice lack PFC inhibiting activity (anti-idiotype antibody). (3) Spleen cells from TNP-F immune NZB mice fail to transfer antiidiotype antibody-mediated suppression to naive mice as do spleen cells from immune nonautoimmune-prone mice. Taken together these data suggest that autoimmune-prone mice are deficient in auto-anti-idiotype antibody-mediated downward regulation of their immune responses. It was further shown that the immune response of NZB mice to TNP-F shows a slower decline in splenic PFC and a greater heterogeneity of PFC affinity than do the responses of non-autoimmune-prone strains. Since athymic (nude) mice, which were previously shown to be defective in the production of auto-anti-idiotype antibody, also show a slower decline in splenic PFC and an increased heterogeneity of PFC affinity, it is suggested that these peculiarities of the immune responses of autoimmune-prone and athymic mice are also the consequences of the lack of autoanti-idiotype antibody-mediated down-regulation.",
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