Studies of immune responses in mice prone to autoimmune disorders. I. Heterogeneity of the affinities of antihapten antibodies produced by NZB, NZW, and related strains of mice

Edmond A. Goidl, Gabriel Fernandes, Marc E. Weksler, Gregory W. Siskind, Robert A. Good

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mice of the NZB and NZW strains and their F1 hybrid produce antihapten plaque-forming cell (PFC) responses to T-dependent antigens (trinitrophenylated bovine gamma globulin and dansylated keyhole limpet hemocyanin) which are of unusually restricted heterogeneity of affinity, are relatively lacking in low-affinity PFC, and are of relatively high average affinity. Since some low-affinity PFC are present in NZB mice early after immunization, the results suggest a particularly marked down-regulation of low-affinity antibody production by these strains. The non-autoimmune-prone F1 hybrid (NZB × CBA) produces a typical heterogeneous response containing a high proportion of low-affinity PFC. Thus, the tendency to down-regulate low-affinity PFC is not inherited as a simple Mendelian dominant trait. The response of NZB mice to T-independent antigens does not show the same restricted heterogeneity of affinity. In fact, late after injections of trinitrophenylated Ficoll, NZB mice tend to have more heterogeneous responses than nonautoimmune-prone BALB/c mice in which a marked down-regulation of high-affinity antibody-producing PFC is seen. The possible relationship between these unusual features of the immune response of NZB and some related strains and their tendency to develop autoimmune disease is discussed.

Original languageEnglish (US)
Pages (from-to)20-30
Number of pages11
JournalCellular Immunology
Volume80
Issue number1
DOIs
StatePublished - 1983

Fingerprint

Antibody Affinity
Inbred NZB Mouse
Down-Regulation
T Independent Antigens
Ficoll
gamma-Globulins
Viral Tumor Antigens
Autoimmune Diseases
Antibody Formation
Immunization
Injections

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Studies of immune responses in mice prone to autoimmune disorders. I. Heterogeneity of the affinities of antihapten antibodies produced by NZB, NZW, and related strains of mice. / Goidl, Edmond A.; Fernandes, Gabriel; Weksler, Marc E.; Siskind, Gregory W.; Good, Robert A.

In: Cellular Immunology, Vol. 80, No. 1, 1983, p. 20-30.

Research output: Contribution to journalArticle

Goidl, Edmond A. ; Fernandes, Gabriel ; Weksler, Marc E. ; Siskind, Gregory W. ; Good, Robert A. / Studies of immune responses in mice prone to autoimmune disorders. I. Heterogeneity of the affinities of antihapten antibodies produced by NZB, NZW, and related strains of mice. In: Cellular Immunology. 1983 ; Vol. 80, No. 1. pp. 20-30.
@article{e6d0936f7e36455987dc9a025655bdd7,
title = "Studies of immune responses in mice prone to autoimmune disorders. I. Heterogeneity of the affinities of antihapten antibodies produced by NZB, NZW, and related strains of mice",
abstract = "Mice of the NZB and NZW strains and their F1 hybrid produce antihapten plaque-forming cell (PFC) responses to T-dependent antigens (trinitrophenylated bovine gamma globulin and dansylated keyhole limpet hemocyanin) which are of unusually restricted heterogeneity of affinity, are relatively lacking in low-affinity PFC, and are of relatively high average affinity. Since some low-affinity PFC are present in NZB mice early after immunization, the results suggest a particularly marked down-regulation of low-affinity antibody production by these strains. The non-autoimmune-prone F1 hybrid (NZB × CBA) produces a typical heterogeneous response containing a high proportion of low-affinity PFC. Thus, the tendency to down-regulate low-affinity PFC is not inherited as a simple Mendelian dominant trait. The response of NZB mice to T-independent antigens does not show the same restricted heterogeneity of affinity. In fact, late after injections of trinitrophenylated Ficoll, NZB mice tend to have more heterogeneous responses than nonautoimmune-prone BALB/c mice in which a marked down-regulation of high-affinity antibody-producing PFC is seen. The possible relationship between these unusual features of the immune response of NZB and some related strains and their tendency to develop autoimmune disease is discussed.",
author = "Goidl, {Edmond A.} and Gabriel Fernandes and Weksler, {Marc E.} and Siskind, {Gregory W.} and Good, {Robert A.}",
year = "1983",
doi = "10.1016/0008-8749(83)90090-4",
language = "English (US)",
volume = "80",
pages = "20--30",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Studies of immune responses in mice prone to autoimmune disorders. I. Heterogeneity of the affinities of antihapten antibodies produced by NZB, NZW, and related strains of mice

AU - Goidl, Edmond A.

AU - Fernandes, Gabriel

AU - Weksler, Marc E.

AU - Siskind, Gregory W.

AU - Good, Robert A.

PY - 1983

Y1 - 1983

N2 - Mice of the NZB and NZW strains and their F1 hybrid produce antihapten plaque-forming cell (PFC) responses to T-dependent antigens (trinitrophenylated bovine gamma globulin and dansylated keyhole limpet hemocyanin) which are of unusually restricted heterogeneity of affinity, are relatively lacking in low-affinity PFC, and are of relatively high average affinity. Since some low-affinity PFC are present in NZB mice early after immunization, the results suggest a particularly marked down-regulation of low-affinity antibody production by these strains. The non-autoimmune-prone F1 hybrid (NZB × CBA) produces a typical heterogeneous response containing a high proportion of low-affinity PFC. Thus, the tendency to down-regulate low-affinity PFC is not inherited as a simple Mendelian dominant trait. The response of NZB mice to T-independent antigens does not show the same restricted heterogeneity of affinity. In fact, late after injections of trinitrophenylated Ficoll, NZB mice tend to have more heterogeneous responses than nonautoimmune-prone BALB/c mice in which a marked down-regulation of high-affinity antibody-producing PFC is seen. The possible relationship between these unusual features of the immune response of NZB and some related strains and their tendency to develop autoimmune disease is discussed.

AB - Mice of the NZB and NZW strains and their F1 hybrid produce antihapten plaque-forming cell (PFC) responses to T-dependent antigens (trinitrophenylated bovine gamma globulin and dansylated keyhole limpet hemocyanin) which are of unusually restricted heterogeneity of affinity, are relatively lacking in low-affinity PFC, and are of relatively high average affinity. Since some low-affinity PFC are present in NZB mice early after immunization, the results suggest a particularly marked down-regulation of low-affinity antibody production by these strains. The non-autoimmune-prone F1 hybrid (NZB × CBA) produces a typical heterogeneous response containing a high proportion of low-affinity PFC. Thus, the tendency to down-regulate low-affinity PFC is not inherited as a simple Mendelian dominant trait. The response of NZB mice to T-independent antigens does not show the same restricted heterogeneity of affinity. In fact, late after injections of trinitrophenylated Ficoll, NZB mice tend to have more heterogeneous responses than nonautoimmune-prone BALB/c mice in which a marked down-regulation of high-affinity antibody-producing PFC is seen. The possible relationship between these unusual features of the immune response of NZB and some related strains and their tendency to develop autoimmune disease is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0020592149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020592149&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(83)90090-4

DO - 10.1016/0008-8749(83)90090-4

M3 - Article

C2 - 6603277

AN - SCOPUS:0020592149

VL - 80

SP - 20

EP - 30

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -