TY - JOUR
T1 - Structure of the chlamydia trachomatis immunodominant antigen Pgp3
AU - Galaleldeen, Ahmad
AU - Taylor, Alexander B.
AU - Chen, Ding
AU - Schuermann, Jonathan P.
AU - Holloway, Stephen P.
AU - Hou, Shuping
AU - Gong, Siqi
AU - Zhong, Guangming
AU - Hart, P. John
PY - 2013/7/26
Y1 - 2013/7/26
N2 - Background: Pgp3 is an immunogenic protein secreted by Chlamydia trachomatis. Results: The trimeric Pgp3 structure reveals globular domains connected by a triple helical coiled-coil. Conclusion: The C-terminal domains resemble tumor necrosis factor, the helical coiled-coil has an unusual twist, and the N-terminal domain is a fusion of virus-like structural motifs. Significance: The Pgp3 structure provides insight into its role in chlamydial pathogenesis.
AB - Background: Pgp3 is an immunogenic protein secreted by Chlamydia trachomatis. Results: The trimeric Pgp3 structure reveals globular domains connected by a triple helical coiled-coil. Conclusion: The C-terminal domains resemble tumor necrosis factor, the helical coiled-coil has an unusual twist, and the N-terminal domain is a fusion of virus-like structural motifs. Significance: The Pgp3 structure provides insight into its role in chlamydial pathogenesis.
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U2 - 10.1074/jbc.M113.475012
DO - 10.1074/jbc.M113.475012
M3 - Article
C2 - 23703617
AN - SCOPUS:84881102201
SN - 0021-9258
VL - 288
SP - 22068
EP - 22079
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 30
ER -