Structure of the chlamydia trachomatis immunodominant antigen Pgp3

Ahmad Galaleldeen, Alexander B. Taylor, Ding Chen, Jonathan P. Schuermann, Stephen P. Holloway, Shuping Hou, Siqi Gong, Guangming Zhong, P. John Hart

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background: Pgp3 is an immunogenic protein secreted by Chlamydia trachomatis. Results: The trimeric Pgp3 structure reveals globular domains connected by a triple helical coiled-coil. Conclusion: The C-terminal domains resemble tumor necrosis factor, the helical coiled-coil has an unusual twist, and the N-terminal domain is a fusion of virus-like structural motifs. Significance: The Pgp3 structure provides insight into its role in chlamydial pathogenesis.

Original languageEnglish (US)
Pages (from-to)22068-22079
Number of pages12
JournalJournal of Biological Chemistry
Issue number30
StatePublished - Jul 26 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology


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