Structure of the chlamydia trachomatis immunodominant antigen Pgp3

Ahmad Galaleldeen, Alexander B. Taylor, Ding Chen, Jonathan P. Schuermann, Stephen P. Holloway, Shuping Hou, Siqi Gong, Guangming Zhong, P. John Hart

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Pgp3 is an immunogenic protein secreted by Chlamydia trachomatis. Results: The trimeric Pgp3 structure reveals globular domains connected by a triple helical coiled-coil. Conclusion: The C-terminal domains resemble tumor necrosis factor, the helical coiled-coil has an unusual twist, and the N-terminal domain is a fusion of virus-like structural motifs. Significance: The Pgp3 structure provides insight into its role in chlamydial pathogenesis.

Original languageEnglish (US)
Pages (from-to)22068-22079
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

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Immunodominant Epitopes
Chlamydia trachomatis
Viruses
Fusion reactions
Tumor Necrosis Factor-alpha
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Galaleldeen, A., Taylor, A. B., Chen, D., Schuermann, J. P., Holloway, S. P., Hou, S., ... Hart, P. J. (2013). Structure of the chlamydia trachomatis immunodominant antigen Pgp3. Journal of Biological Chemistry, 288(30), 22068-22079. https://doi.org/10.1074/jbc.M113.475012

Structure of the chlamydia trachomatis immunodominant antigen Pgp3. / Galaleldeen, Ahmad; Taylor, Alexander B.; Chen, Ding; Schuermann, Jonathan P.; Holloway, Stephen P.; Hou, Shuping; Gong, Siqi; Zhong, Guangming; Hart, P. John.

In: Journal of Biological Chemistry, Vol. 288, No. 30, 26.07.2013, p. 22068-22079.

Research output: Contribution to journalArticle

Galaleldeen, A, Taylor, AB, Chen, D, Schuermann, JP, Holloway, SP, Hou, S, Gong, S, Zhong, G & Hart, PJ 2013, 'Structure of the chlamydia trachomatis immunodominant antigen Pgp3', Journal of Biological Chemistry, vol. 288, no. 30, pp. 22068-22079. https://doi.org/10.1074/jbc.M113.475012
Galaleldeen A, Taylor AB, Chen D, Schuermann JP, Holloway SP, Hou S et al. Structure of the chlamydia trachomatis immunodominant antigen Pgp3. Journal of Biological Chemistry. 2013 Jul 26;288(30):22068-22079. https://doi.org/10.1074/jbc.M113.475012
Galaleldeen, Ahmad ; Taylor, Alexander B. ; Chen, Ding ; Schuermann, Jonathan P. ; Holloway, Stephen P. ; Hou, Shuping ; Gong, Siqi ; Zhong, Guangming ; Hart, P. John. / Structure of the chlamydia trachomatis immunodominant antigen Pgp3. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 30. pp. 22068-22079.
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