Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng; Marie A. Harris; Nandini Ghosh-Choudhury; Mei Feng; Gregory R. Mundy; Stephen E. Harris

doi:10.1016/0167-4781(94)90017-5

Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng
, Marie A. Harris
, Nandini Ghosh-Choudhury
, Mei Feng
, Gregory R. Mundy
, Stephen E. Harris

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

Original language	English (US)
Pages (from-to)	221-224
Number of pages	4
Journal	BBA - Gene Structure and Expression
Volume	1218
Issue number	2
DOIs	https://doi.org/10.1016/0167-4781(94)90017-5
State	Published - Jun 21 1994

Keywords

(Mouse)
Bone morphogenetic protein 2
Nucleotide sequence
genomic DNA

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/0167-4781(94)90017-5

Cite this

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title = "Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes",

abstract = "Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90\% identity at the amino acid level.",

keywords = "(Mouse), Bone morphogenetic protein 2, Nucleotide sequence, genomic DNA",

author = "Feng, \{Jian Q.\} and Harris, \{Marie A.\} and Nandini Ghosh-Choudhury and Mei Feng and Mundy, \{Gregory R.\} and Harris, \{Stephen E.\}",

year = "1994",

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doi = "10.1016/0167-4781(94)90017-5",

language = "English (US)",

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TY - JOUR

T1 - Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2)

T2 - Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

AU - Feng, Jian Q.

AU - Harris, Marie A.

AU - Ghosh-Choudhury, Nandini

AU - Feng, Mei

AU - Mundy, Gregory R.

AU - Harris, Stephen E.

PY - 1994/6/21

Y1 - 1994/6/21

N2 - Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

AB - Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

KW - (Mouse)

KW - Bone morphogenetic protein 2

KW - Nucleotide sequence

KW - genomic DNA

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AN - SCOPUS:0028242526

SN - 0167-4781

VL - 1218

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JO - BBA - Gene Structure and Expression

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IS - 2

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Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Abstract

Keywords

ASJC Scopus subject areas

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