Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng; Marie A. Harris; Nandini Ghosh-Choudhury; Mei Feng; Gregory R. Mundy; Stephen E. Harris

doi:10.1016/0167-4781(94)90017-5

Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng, Marie A. Harris, Nandini Ghosh-Choudhury, Mei Feng, Gregory R. Mundy, Stephen E. Harris

Research output: Contribution to journal › Article

70 Scopus citations

Abstract

Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

Original language	English (US)
Pages (from-to)	221-224
Number of pages	4
Journal	BBA - Gene Structure and Expression
Volume	1218
Issue number	2
DOIs	https://doi.org/10.1016/0167-4781(94)90017-5
State	Published - Jun 21 1994

Keywords

(Mouse)
Bone morphogenetic protein 2
Nucleotide sequence
genomic DNA

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

Access to Document

10.1016/0167-4781(94)90017-5

Fingerprint Dive into the research topics of 'Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes'. Together they form a unique fingerprint.

Cite this

Feng, J. Q., Harris, M. A., Ghosh-Choudhury, N., Feng, M., Mundy, G. R., & Harris, S. E. (1994). Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. BBA - Gene Structure and Expression, 1218(2), 221-224. https://doi.org/10.1016/0167-4781(94)90017-5

Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2) : Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. / Feng, Jian Q.; Harris, Marie A.; Ghosh-Choudhury, Nandini; Feng, Mei; Mundy, Gregory R.; Harris, Stephen E.

In: BBA - Gene Structure and Expression, Vol. 1218, No. 2, 21.06.1994, p. 221-224.

Research output: Contribution to journal › Article

@article{2a3628f1cce1494194fd46dedf2096d8,

title = "Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes",

abstract = "Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.",

keywords = "(Mouse), Bone morphogenetic protein 2, Nucleotide sequence, genomic DNA",

author = "Feng, {Jian Q.} and Harris, {Marie A.} and Nandini Ghosh-Choudhury and Mei Feng and Mundy, {Gregory R.} and Harris, {Stephen E.}",

year = "1994",

month = jun,

day = "21",

doi = "10.1016/0167-4781(94)90017-5",

language = "English (US)",

volume = "1218",

pages = "221--224",

journal = "Biochimica et Biophysica Acta - Gene Structure and Expression",

issn = "0167-4781",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2)

T2 - Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

AU - Feng, Jian Q.

AU - Harris, Marie A.

AU - Ghosh-Choudhury, Nandini

AU - Feng, Mei

AU - Mundy, Gregory R.

AU - Harris, Stephen E.

PY - 1994/6/21

Y1 - 1994/6/21

N2 - Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

AB - Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

KW - (Mouse)

KW - Bone morphogenetic protein 2

KW - Nucleotide sequence

KW - genomic DNA

UR - http://www.scopus.com/inward/record.url?scp=0028242526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028242526&partnerID=8YFLogxK

U2 - 10.1016/0167-4781(94)90017-5

DO - 10.1016/0167-4781(94)90017-5

M3 - Article

C2 - 8018727

AN - SCOPUS:0028242526

VL - 1218

SP - 221

EP - 224

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

SN - 0167-4781

IS - 2

ER -