Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng, Marie A. Harris, Nandini Ghosh-Choudhury, Mei Feng, Gregory R. Mundy, Stephen E. Harris

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalBBA - Gene Structure and Expression
Volume1218
Issue number2
DOIs
StatePublished - Jun 21 1994

Keywords

  • (Mouse)
  • Bone morphogenetic protein 2
  • Nucleotide sequence
  • genomic DNA

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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