Abstract
Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.
Original language | English (US) |
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Pages (from-to) | 221-224 |
Number of pages | 4 |
Journal | BBA - Gene Structure and Expression |
Volume | 1218 |
Issue number | 2 |
DOIs | |
State | Published - Jun 21 1994 |
Keywords
- (Mouse)
- Bone morphogenetic protein 2
- Nucleotide sequence
- genomic DNA
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Genetics