Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng; Marie A. Harris; Nandini Ghosh-Choudhury; Mei Feng; Gregory R. Mundy; Stephen E. Harris

doi:10.1016/0167-4781(94)90017-5

Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Jian Q. Feng, Marie A. Harris, Nandini Ghosh-Choudhury, Mei Feng, Gregory R. Mundy, Stephen E. Harris

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

Original language	English (US)
Pages (from-to)	221-224
Number of pages	4
Journal	BBA - Gene Structure and Expression
Volume	1218
Issue number	2
DOIs	https://doi.org/10.1016/0167-4781(94)90017-5
State	Published - Jun 21 1994

Keywords

(Mouse)
Bone morphogenetic protein 2
Nucleotide sequence
genomic DNA

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/0167-4781(94)90017-5

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Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2) : Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. / Feng, Jian Q.; Harris, Marie A.; Ghosh-Choudhury, Nandini; Feng, Mei; Mundy, Gregory R.; Harris, Stephen E.

In: BBA - Gene Structure and Expression, Vol. 1218, No. 2, 21.06.1994, p. 221-224.

Research output: Contribution to journal › Article › peer-review

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abstract = "Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains ∼ 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.",

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AU - Mundy, Gregory R.

AU - Harris, Stephen E.

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KW - Nucleotide sequence

KW - genomic DNA

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Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Abstract

Keywords

ASJC Scopus subject areas

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