Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian, Veronika Souslova, Lucia Sivilotti, John N. Wood

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalFEBS Letters
Volume400
Issue number2
DOIs
Publication statusPublished - Jan 3 1997

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Keywords

  • Dorsal root ganglion
  • Voltage-gated sodium channel
  • cDNA cloning

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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