Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian; Veronika Souslova; Lucia Sivilotti; John N. Wood

doi:10.1016/S0014-5793(96)01389-0

Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian, Veronika Souslova, Lucia Sivilotti, John N. Wood

Endodontics

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58 Scopus citations

Abstract

A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na⁺ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	FEBS Letters
Volume	400
Issue number	2
DOIs	https://doi.org/10.1016/S0014-5793(96)01389-0
Publication status	Published - Jan 3 1997

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Keywords

Dorsal root ganglion
Voltage-gated sodium channel
cDNA cloning

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Cite this

Akopian, A. N., Souslova, V., Sivilotti, L., & Wood, J. N. (1997). Structure and distribution of a broadly expressed atypical sodium channel. FEBS Letters, 400(2), 183-187. https://doi.org/10.1016/S0014-5793(96)01389-0

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10.1016/S0014-5793(96)01389-0