Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian; Veronika Souslova; Lucia Sivilotti; John N. Wood

doi:10.1016/S0014-5793(96)01389-0

Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian, Veronika Souslova, Lucia Sivilotti, John N. Wood

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na⁺ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	FEBS Letters
Volume	400
Issue number	2
DOIs	https://doi.org/10.1016/S0014-5793(96)01389-0
State	Published - Jan 3 1997
Externally published	Yes

Keywords

Dorsal root ganglion
Voltage-gated sodium channel
cDNA cloning

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Structure and distribution of a broadly expressed atypical sodium channel",

abstract = "A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.",

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AU - Akopian, Armen N.

AU - Souslova, Veronika

AU - Sivilotti, Lucia

AU - Wood, John N.

N1 - Funding Information: We thank the Royal Society, The Wellcome Trust, and the MRC for support.

PY - 1997/1/3

Y1 - 1997/1/3

N2 - A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

AB - A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

KW - Dorsal root ganglion

KW - Voltage-gated sodium channel

KW - cDNA cloning

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Structure and distribution of a broadly expressed atypical sodium channel

Abstract

Keywords

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