Structural properties of fracture haematoma: current status and future clinical implications

Xin Wang, Thor Friis, Vaida Glatt, Ross Crawford, Yin Xiao

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Blood clots (haematomas) that form immediately following a bone fracture have been shown to be vital for the subsequent healing process. During the clotting process, a number of factors can influence the fibrin clot structure, such as fibrin polymerization, growth factor binding, cellular infiltration (including platelet retraction), protein concentrations and cytokines. The modulation of the fibrin clot structure within the fracture site has important clinical implications and could result in the development of multifunctional scaffolds that mimic the natural structure of a haematoma. Artificial haematoma structures such as these can be created from the patient's own blood and can therefore act as an ideal bone defect filling material for potential clinical application to accelerate bone regeneration.

Original languageEnglish (US)
Pages (from-to)2864-2875
Number of pages12
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

Keywords

  • blood clot
  • fibrin clot
  • fracture haematoma
  • large bone defect
  • structural properties

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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