Structural brain changes in bipolar disorder using deformation field morphometry

Jair C. Soares, Peter Kochunov, E. Serap Monkul, Mark A. Nicoletti, Paolo Brambilla, Roberto B. Sassi, Alan G. Mallinger, Ellen Frank, David J. Kupfer, Jack Lancaster, Peter Fox

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The objective of this study was to investigate anatomical brain abnormalities in adult bipolar patients using a deformation field morphometry technique. Our sample consisted of 32 right-handed bipolar I patients (men/women=16/16) and 32 right-handed, age and gender matched healthy controls. Deformation field morphometry analysis was performed on three-dimensional spoiled gradient recalled acquisition images. We found gender-specific structural differences between bipolar patients and healthy individuals. Bipolar men had significantly larger lateral ventricles (especially pronounced in the left hemisphere) and smaller left dorsolateral prefrontal cortex than healthy male controls. Our results are complementary to the findings of functional imaging and post-mortem studies that demonstrate abnormalities in the dorsolateral prefrontal cortex in bipolar patients.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
Issue number6
StatePublished - Apr 25 2005


  • Bipolar disorder
  • Magnetic resonance imaging
  • Mood disorders
  • Morphometry
  • Neuroimaging
  • Structural

ASJC Scopus subject areas

  • Neuroscience(all)


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