Structural Brain Architectures Match Intrinsic Functional Networks and Vary across Domains: A Study from 15 000+ Individuals

Na Luo, Jing Sui, Anees Abrol, Jiayu Chen, Jessica A. Turner, Eswar Damaraju, Zening Fu, Lingzhong Fan, Dongdong Lin, Chuanjun Zhuo, Yong Xu, David C. Glahn, Amanda L. Rodrigue, Marie T. Banich, Godfrey D. Pearlson, Vince D. Calhoun

Research output: Contribution to journalArticle

Abstract

Brain structural networks have been shown to consistently organize in functionally meaningful architectures covering the entire brain. However, to what extent brain structural architectures match the intrinsic functional networks in different functional domains remains under explored. In this study, based on independent component analysis, we revealed 45 pairs of structural-functional (S-F) component maps, distributing across nine functional domains, in both a discovery cohort (n = 6005) and a replication cohort (UK Biobank, n = 9214), providing a well-match multimodal spatial map template for public use. Further network module analysis suggested that unimodal cortical areas (e.g., somatomotor and visual networks) indicate higher S-F coherence, while heteromodal association cortices, especially the frontoparietal network (FPN), exhibit more S-F divergence. Collectively, these results suggest that the expanding and maturing brain association cortex demonstrates a higher degree of changes compared with unimodal cortex, which may lead to higher interindividual variability and lower S-F coherence.

Original languageEnglish (US)
Pages (from-to)5460-5470
Number of pages11
JournalCerebral cortex (New York, N.Y. : 1991)
Volume30
Issue number10
DOIs
StatePublished - Sep 3 2020
Externally publishedYes

Keywords

  • heteromodal association cortex
  • independent component analysis (ICA)
  • intrinsic brain networks
  • structure-function coherence
  • unimodal cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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  • Cite this

    Luo, N., Sui, J., Abrol, A., Chen, J., Turner, J. A., Damaraju, E., Fu, Z., Fan, L., Lin, D., Zhuo, C., Xu, Y., Glahn, D. C., Rodrigue, A. L., Banich, M. T., Pearlson, G. D., & Calhoun, V. D. (2020). Structural Brain Architectures Match Intrinsic Functional Networks and Vary across Domains: A Study from 15 000+ Individuals. Cerebral cortex (New York, N.Y. : 1991), 30(10), 5460-5470. https://doi.org/10.1093/cercor/bhaa127