Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Brian Krumm; Yan Xiang; Junpeng Deng

doi:10.1002/pro.2441

Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Brian Krumm, Yan Xiang, Junpeng Deng

Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.

Original language	English (US)
Pages (from-to)	526-538
Number of pages	13
Journal	Protein Science
Volume	23
Issue number	5
DOIs	https://doi.org/10.1002/pro.2441
State	Published - May 2014

Keywords

Agonist
Antagonist
Cytokine
Inflammation
Interleukin
Receptors

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1002/pro.2441

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abstract = "Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.",

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Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Abstract

Keywords

ASJC Scopus subject areas

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