Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Brian Krumm, Yan Xiang, Junpeng Deng

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.

Original languageEnglish (US)
Pages (from-to)526-538
Number of pages13
JournalProtein Science
Volume23
Issue number5
DOIs
StatePublished - May 2014

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Keywords

  • Agonist
  • Antagonist
  • Cytokine
  • Inflammation
  • Interleukin
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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