Abstract
Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
Original language | English (US) |
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Pages (from-to) | 526-538 |
Number of pages | 13 |
Journal | Protein Science |
Volume | 23 |
Issue number | 5 |
DOIs | |
State | Published - May 2014 |
Keywords
- Agonist
- Antagonist
- Cytokine
- Inflammation
- Interleukin
- Receptors
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry