Structural and mechanistic relationships between nucleic acid polymerases

Rui Sousa

Research output: Contribution to journalReview articlepeer-review

143 Scopus citations


A superfamily of nucleic acid polymerases that includes the pol I and pol α classes of DNA-directed DNA polymerases, mitochondrial and phage DNA-directed RNA polymerases, and most RNA-directed polymerases may be defined on the basis of the occurrence of conserved sequence motifs and tertiary structure similarities between HIV-1 reverse transcriptase, DNA polymerase I and T7 RNA polymerase. Although sequence or structural similarities do not yet justify inclusion of the multi-subunit DNA-directed RNA polymerases in this superfamily, mechanistic similarities suggest a deep relationship between these and the simpler T7-like RNA polymerases.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalTrends in Biochemical Sciences
Issue number5
StatePublished - May 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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