Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range

Diedre Winnier, Luke Norton, Mustafa Kanat, Ruth Arya, Marcel Fourcaudot, Andrea Hansis-Diarte, Devjit Tripathy, Ralph A Defronzo, Christopher P. Jenkinson, Muhammad A Abdul-ghani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: The aim of this study was to examine the relationship between whole-body insulin-mediated glucose disposal and the fasting plasma glucose concentration in nondiabetic individuals. Copyright

Research Design and Methods: Two hundred fifty-three nondiabetic subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance received a 75-g oral glucose tolerance test and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG andNGTindividuals and was related to fasting and 2-hour plasma glucose concentrations in each group.

Results: TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2-hour plasma glucose (PG; r < 0.40, P < .0001) but not with the fasting PG. WhenIFG and NGT individuals were stratified based on their 2-hour PG concentration, the increase in 2-hour PG was associated with a progressive decrease in TGD in both groups, and the TGD was comparable among NGT and IFG individuals.

Conclusion: The present results indicate the following: 1) as in NGT, insulin-stimulated TGD varies considerably in IFG individuals; 2) the large variability in TGD in IFG and NGT individuals is related to the 2-hour PG concentration; and 3) after adjustment for the 2-hour proglucagon concentration, IFG subjects have comparable TGD with NGT individuals.

Original languageEnglish (US)
Pages (from-to)3444-3449
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number9
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Fingerprint

Fasting
Insulin
Plasmas
Glucose
Glucose Intolerance
Clamping devices
Proglucagon
Glucose Clamp Technique
Glucose Tolerance Test

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range. / Winnier, Diedre; Norton, Luke; Kanat, Mustafa; Arya, Ruth; Fourcaudot, Marcel; Hansis-Diarte, Andrea; Tripathy, Devjit; Defronzo, Ralph A; Jenkinson, Christopher P.; Abdul-ghani, Muhammad A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 9, 01.09.2014, p. 3444-3449.

Research output: Contribution to journalArticle

Winnier, Diedre ; Norton, Luke ; Kanat, Mustafa ; Arya, Ruth ; Fourcaudot, Marcel ; Hansis-Diarte, Andrea ; Tripathy, Devjit ; Defronzo, Ralph A ; Jenkinson, Christopher P. ; Abdul-ghani, Muhammad A. / Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range. In: Journal of Clinical Endocrinology and Metabolism. 2014 ; Vol. 99, No. 9. pp. 3444-3449.
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AU - Fourcaudot, Marcel

AU - Hansis-Diarte, Andrea

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