Striatal volumes in pediatric bipolar patients with and without comorbid ADHD

Isabelle Yisha Liu, Meghan Howe, Amy Garrett, Asya Karchemskiy, Ryan Kelley, Dylan Alegria, Allan Reiss, Kiki Chang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n= 17), BD without comorbid ADHD (n= 12), youth with ADHD alone (n= 11), and healthy control subjects (n= 24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using BrainImageJava software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalPsychiatry Research - Neuroimaging
Issue number1
StatePublished - Oct 31 2011
Externally publishedYes


  • Basal ganglia
  • Caudate nucleus
  • Magnetic resonance imaging
  • Striatum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)


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