TY - JOUR
T1 - Striatal volumes in pediatric bipolar patients with and without comorbid ADHD
AU - Liu, Isabelle Yisha
AU - Howe, Meghan
AU - Garrett, Amy
AU - Karchemskiy, Asya
AU - Kelley, Ryan
AU - Alegria, Dylan
AU - Reiss, Allan
AU - Chang, Kiki
N1 - Funding Information:
This work was supported in part by NIMH grant MH64460, a grant from the Klingenstein Third Generation Foundation, the Hahn family, and a grant from the Stanford University Undergraduate Research Programs, administered by the Office of the Vice Provost for Undergraduate Education. We also thank the Howard Hughes Medical Institute for support of our research.
PY - 2011/10/31
Y1 - 2011/10/31
N2 - The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n= 17), BD without comorbid ADHD (n= 12), youth with ADHD alone (n= 11), and healthy control subjects (n= 24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using BrainImageJava software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.
AB - The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n= 17), BD without comorbid ADHD (n= 12), youth with ADHD alone (n= 11), and healthy control subjects (n= 24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using BrainImageJava software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.
KW - Basal ganglia
KW - Caudate nucleus
KW - Magnetic resonance imaging
KW - Striatum
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U2 - 10.1016/j.pscychresns.2011.06.008
DO - 10.1016/j.pscychresns.2011.06.008
M3 - Article
C2 - 21875781
AN - SCOPUS:80053385309
SN - 0925-4927
VL - 194
SP - 14
EP - 20
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -