Stressor-specific increase of vasopressin mRNA in paraventricular hypophysiotrophic neurons

Viktor Bartanusz, Jean Michel Aubry, Thierry Steimer, Judit Baffi, Jozsef Z. Kiss

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Cellular levels of vasopressin (VP) and corticotropin-releasing factor (CRF) RNA transcripts were determined in hypophysiotrophic neurons after open-field and immobilization stress using quantitative in situ hybridization. We found that 8 min open-field stress is sufficient to produce a significant up-regulation of CRF mRNA, without any concomitant changes in the level of VP mRNA. In contrast, 8 min immobilization stress resulted in an increased labeling density of both CRF and VP mRNAs. These results suggest that the level of CRF and VP transcripts in parvicellular hypophysiotrophic neurons is differentially regulated in a stressor-specific manner.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalNeuroscience Letters
Volume170
Issue number1
DOIs
Publication statusPublished - Mar 28 1994

    Fingerprint

Keywords

  • CRF
  • Hypothalamic paraventricular nucleus
  • Immobilization
  • In situ hybridization
  • Open-field
  • Stress
  • Vasopressin
  • mRNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this