TY - JOUR
T1 - Stress ulcer disease in the burned patient
AU - Pruitt, Basil A.
AU - Goodwin, Cleon W.
PY - 1981/3/1
Y1 - 1981/3/1
N2 - Stress-induced ulcers of the stomach and duodenum in massively burned patients, otherwise known as Curling's ulcers, result from a defect in the mucosal barrier to secreted acid. The etiology of this defect is related, at least in part, to mucosal ischemia, which is aggravated by hypotension, sepsis, and hypoxia. Early prophylactic administration of antacids and cimetidine, either singly or in combination, has significantly reduced the occurrence of the life-threatening complications of these lesions. When preventive measures have failed or have not been utilized and massive bleeding or perforation has occurred, these complications of Curling's ulcer appear to be best treated by gastric resection combined with vagotomy.
AB - Stress-induced ulcers of the stomach and duodenum in massively burned patients, otherwise known as Curling's ulcers, result from a defect in the mucosal barrier to secreted acid. The etiology of this defect is related, at least in part, to mucosal ischemia, which is aggravated by hypotension, sepsis, and hypoxia. Early prophylactic administration of antacids and cimetidine, either singly or in combination, has significantly reduced the occurrence of the life-threatening complications of these lesions. When preventive measures have failed or have not been utilized and massive bleeding or perforation has occurred, these complications of Curling's ulcer appear to be best treated by gastric resection combined with vagotomy.
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U2 - 10.1007/BF01658293
DO - 10.1007/BF01658293
M3 - Article
C2 - 7245792
AN - SCOPUS:0019864425
VL - 5
SP - 209
EP - 220
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 2
ER -