Stress modulation of cognitive and affective processes

Serge Campeau, Israel Liberzon, David Morilak, Kerry Ressler

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


This review summarizes the major discussion points of a symposium on stress modulation of cognitive and affective processes, which was held during the 2010 workshop on the neurobiology of stress (Boulder, CO, USA). The four discussants addressed a number of specific cognitive and affective factors that are modulated by exposure to acute or repeated stress. Dr David Morilak discussed the effects of various repeated stress situations on cognitive flexibility, as assessed with a rodent model of attentional set-shifting task, and how performance on slightly different aspects of this test is modulated by different prefrontal regions through monoaminergic neurotransmission. Dr Serge Campeau summarized the findings of several studies exploring a number of factors and brain regions that regulate habituation of various autonomic and neuroendocrine responses to repeated audiogenic stress exposures. Dr Kerry Ressler discussed a body of work exploring the modulation and extinction of fear memories in rodents and humans, especially focusing on the role of key neurotransmitter systems including excitatory amino acids and brain-derived neurotrophic factor. Dr Israel Liberzon presented recent results on human decision-making processes in response to exogenous glucocorticoid hormone administration. Overall, these discussions are casting a wider framework on the cognitive/affective processes that are distinctly regulated by the experience of stress and some of the brain regions and neurotransmitter systems associated with these effects.

Original languageEnglish (US)
Pages (from-to)503-519
Number of pages17
Issue number5
StatePublished - Sep 2011


  • Cognitive flexibility
  • decision making
  • extinction
  • fear conditioning
  • habituation
  • prefrontal cortex

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Physiology
  • Behavioral Neuroscience


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