Stress in surgical patients as a neurophysiologic reflex response

D. W. Wilmore, J. M. Long, A. D. Mason, B. A. Pruitt

Research output: Contribution to journalReview article

82 Scopus citations


Man's adaptations to threatening external stimuli or to changes in the internal milieu of the body are fundamental homeostatic responses paramount to survival. In surgical patients, hemorrhage, injury, infection, pain and anxiety are common stimuli which elicit a neuroendocrine response, a major component of the pathophysiologic factors or many diseases treated by surgeons. This study reviews the stress induced reflex arc in injured humans, describes the integrated hypothalamic response to stress and quantifies the final neuroendocrine and metabolic changes which cause the altered physiologic equilibrium. 124 References are cited.

Original languageEnglish (US)
Pages (from-to)257-269
Number of pages13
JournalSurgery Gynecology and Obstetrics
Issue number2
StatePublished - Dec 1 1976


ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Cite this

Wilmore, D. W., Long, J. M., Mason, A. D., & Pruitt, B. A. (1976). Stress in surgical patients as a neurophysiologic reflex response. Surgery Gynecology and Obstetrics, 142(2), 257-269.