Streptozotocin-induced diabetes differentially modifies haloperidol- and γ-hydroxybutyric acid (GHB)-induced catalepsy

Rajkumar J. Sevak, Wouter Koek, Charles P. France

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

To examine whether dopamine-mediated behavioral effects are altered in diabetes, this study compared the cataleptic effects of the dopamine receptor antagonist haloperidol (0.032-0.56 mg/kg) and γ-hydroxybutyric acid (GHB; 56-1000 mg/kg) in control and streptozotocin (STZ)-treated rats. Haloperidol and GHB produced catalepsy in control and diabetic rats; haloperidol was less potent in diabetic rats (D50 = 0.44 mg/kg) than in controls (D 50 = 0.19 mg/kg), while GHB was more potent in diabetic rats (D 50 = 392 mg/kg) than in controls (D50 = 550 mg/kg). In diabetic rats, the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (0.32 mg/kg) further attenuated haloperidol-induced catalepsy (D50 = 1.2 mg/kg) and further enhanced GHB-induced catalepsy (D50 = 248 mg/kg). That haloperidol is less potent to produce catalepsy in diabetic rats is consistent with reports of altered dopamine receptor binding in diabetes.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalEuropean Journal of Pharmacology
Volume517
Issue number1-2
DOIs
StatePublished - Jul 4 2005

Keywords

  • D2 receptors
  • Dizocilpine
  • Haloperidol
  • Streptozotocin
  • γ-hydroxybutyric acid

ASJC Scopus subject areas

  • Pharmacology

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