Abstract
In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 581-593 |
| Number of pages | 13 |
| Journal | Statistical Methods in Medical Research |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Epidemiology
- Health Information Management
- Statistics and Probability
Cite this
Stratified and randomized play-the-winner rule. / Liang, Yuanyuan; Carriere, Kimmie Chough.
In: Statistical Methods in Medical Research, Vol. 17, No. 6, 2008, p. 581-593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stratified and randomized play-the-winner rule
AU - Liang, Yuanyuan
AU - Carriere, Kimmie Chough
PY - 2008
Y1 - 2008
N2 - In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.
AB - In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.
UR - http://www.scopus.com/inward/record.url?scp=58749114233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58749114233&partnerID=8YFLogxK
U2 - 10.1177/0962280207081606
DO - 10.1177/0962280207081606
M3 - Article
C2 - 18375460
AN - SCOPUS:58749114233
VL - 17
SP - 581
EP - 593
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
SN - 0962-2802
IS - 6
ER -