Stratified and randomized play-the-winner rule

Yuanyuan Liang; Kimmie Chough Carriere

doi:10.1177/0962280207081606

Stratified and randomized play-the-winner rule

Yuanyuan Liang, Kimmie Chough Carriere

Epidemiology & Biostatistics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.

Original language	English (US)
Pages (from-to)	581-593
Number of pages	13
Journal	Statistical Methods in Medical Research
Volume	17
Issue number	6
DOIs	https://doi.org/10.1177/0962280207081606
State	Published - 2008

ASJC Scopus subject areas

Epidemiology
Statistics and Probability
Health Information Management

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