Stratified and randomized play-the-winner rule

Yuanyuan Liang, Kimmie Chough Carriere

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.

Original languageEnglish (US)
Pages (from-to)581-593
Number of pages13
JournalStatistical Methods in Medical Research
Volume17
Issue number6
DOIs
StatePublished - 2008
Externally publishedYes

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Therapeutics
Selection Bias
Clinical Trials
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ASJC Scopus subject areas

  • Epidemiology
  • Health Information Management
  • Statistics and Probability

Cite this

Stratified and randomized play-the-winner rule. / Liang, Yuanyuan; Carriere, Kimmie Chough.

In: Statistical Methods in Medical Research, Vol. 17, No. 6, 2008, p. 581-593.

Research output: Contribution to journalArticle

Liang, Yuanyuan ; Carriere, Kimmie Chough. / Stratified and randomized play-the-winner rule. In: Statistical Methods in Medical Research. 2008 ; Vol. 17, No. 6. pp. 581-593.
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