Strategy for standardization of preeclampsia research study design

Leslie Myatt, Christopher W. Redman, Anne Cathrine Staff, Stefan Hansson, Melissa L. Wilson, Hannele Laivuori, Lucilla Poston, James M. Roberts

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Preeclampsia remains a major problem worldwide for mothers and babies. Despite intensive study, we have not been able to improve the management or early recognition of preeclampsia. At least part of this is because of failure to standardize the approach to studying this complex syndrome. It is possible that within the syndrome there may be different phenotypes with pathogenic pathways that differ between the subtypes. The capacity to recognize and to exploit different subtypes is of obvious importance for prediction, prevention, and treatment. We present a strategy for research to study preeclampsia, which will allow discrimination of such possible subtypes and also allow comparison and perhaps combinations of findings in different studies by standardized data and biosample collection. To make studies relevant to current clinical practice, the definition of preeclampsia can be that currently used and accepted. However, more importantly, sufficient data should be collected to allow other diagnostic criteria to be used and applied retrospectively. To that end, we present what we consider to be the minimum requirements for a data set in a study of preeclampsia that will facilitate comparisons. We also present a comprehensive or optimal data set for in-depth investigation of pathophysiology. As we approach the definition of phenotypes of preeclampsia by clinical and biochemical criteria, adherence to standardized protocols will hasten our understanding of the causes of preeclampsia and development of targeted treatment strategies.

Original languageEnglish (US)
Pages (from-to)1293-1301
Number of pages9
JournalHypertension
Volume63
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Pre-Eclampsia
Research Design
Phenotype
Therapeutics
Research

Keywords

  • Hypertension
  • Placenta
  • Pre-eclampsia
  • Pregnancy
  • Proteinuria

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Myatt, L., Redman, C. W., Staff, A. C., Hansson, S., Wilson, M. L., Laivuori, H., ... Roberts, J. M. (2014). Strategy for standardization of preeclampsia research study design. Hypertension, 63(6), 1293-1301. https://doi.org/10.1161/HYPERTENSIONAHA.113.02664

Strategy for standardization of preeclampsia research study design. / Myatt, Leslie; Redman, Christopher W.; Staff, Anne Cathrine; Hansson, Stefan; Wilson, Melissa L.; Laivuori, Hannele; Poston, Lucilla; Roberts, James M.

In: Hypertension, Vol. 63, No. 6, 2014, p. 1293-1301.

Research output: Contribution to journalArticle

Myatt, L, Redman, CW, Staff, AC, Hansson, S, Wilson, ML, Laivuori, H, Poston, L & Roberts, JM 2014, 'Strategy for standardization of preeclampsia research study design', Hypertension, vol. 63, no. 6, pp. 1293-1301. https://doi.org/10.1161/HYPERTENSIONAHA.113.02664
Myatt L, Redman CW, Staff AC, Hansson S, Wilson ML, Laivuori H et al. Strategy for standardization of preeclampsia research study design. Hypertension. 2014;63(6):1293-1301. https://doi.org/10.1161/HYPERTENSIONAHA.113.02664
Myatt, Leslie ; Redman, Christopher W. ; Staff, Anne Cathrine ; Hansson, Stefan ; Wilson, Melissa L. ; Laivuori, Hannele ; Poston, Lucilla ; Roberts, James M. / Strategy for standardization of preeclampsia research study design. In: Hypertension. 2014 ; Vol. 63, No. 6. pp. 1293-1301.
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