Strategy and model building in the fourth dimension

a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Vincent P. Diego, Laura Almasy, Thomas D. Dyer, Júlia M P Soler, John Blangero

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

Original languageEnglish (US)
Article numberS34
JournalBMC Genetics
Volume4 Suppl 1
StatePublished - 2003
Externally publishedYes

Fingerprint

Stochastic Processes
Genotype
Blood Pressure
Fasting
Phenotype
Glucose
Chromosomes, Human, Pair 17
Quantitative Trait Loci

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Strategy and model building in the fourth dimension : a null model for genotype x age interaction as a Gaussian stationary stochastic process. / Diego, Vincent P.; Almasy, Laura; Dyer, Thomas D.; Soler, Júlia M P; Blangero, John.

In: BMC Genetics, Vol. 4 Suppl 1, S34, 2003.

Research output: Contribution to journalArticle

Diego, Vincent P. ; Almasy, Laura ; Dyer, Thomas D. ; Soler, Júlia M P ; Blangero, John. / Strategy and model building in the fourth dimension : a null model for genotype x age interaction as a Gaussian stationary stochastic process. In: BMC Genetics. 2003 ; Vol. 4 Suppl 1.
@article{55a313b010d442729276afacf5fc8113,
title = "Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.",
abstract = "Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.",
author = "Diego, {Vincent P.} and Laura Almasy and Dyer, {Thomas D.} and Soler, {J{\'u}lia M P} and John Blangero",
year = "2003",
language = "English (US)",
volume = "4 Suppl 1",
journal = "BMC Genetics",
issn = "1471-2156",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Strategy and model building in the fourth dimension

T2 - a null model for genotype x age interaction as a Gaussian stationary stochastic process.

AU - Diego, Vincent P.

AU - Almasy, Laura

AU - Dyer, Thomas D.

AU - Soler, Júlia M P

AU - Blangero, John

PY - 2003

Y1 - 2003

N2 - Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

AB - Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

UR - http://www.scopus.com/inward/record.url?scp=34248670834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248670834&partnerID=8YFLogxK

M3 - Article

VL - 4 Suppl 1

JO - BMC Genetics

JF - BMC Genetics

SN - 1471-2156

M1 - S34

ER -