Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Vincent P. Diego; Laura Almasy; Thomas D. Dyer; Júlia M.P. Soler; John Blangero

Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Vincent P. Diego, Laura Almasy, Thomas D. Dyer, Júlia M.P. Soler, John Blangero

Research output: Contribution to journal › Article › peer-review

Abstract

Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

Original language	English (US)
Journal	BMC genetics
Volume	4 Suppl 1
State	Published - 2003

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.",

abstract = "Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.",

author = "Diego, {Vincent P.} and Laura Almasy and Dyer, {Thomas D.} and Soler, {J{\'u}lia M.P.} and John Blangero",

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T2 - a null model for genotype x age interaction as a Gaussian stationary stochastic process.

AU - Diego, Vincent P.

AU - Almasy, Laura

AU - Dyer, Thomas D.

AU - Soler, Júlia M.P.

AU - Blangero, John

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2003

Y1 - 2003

N2 - Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

AB - Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

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VL - 4 Suppl 1

JO - BMC Genetics

JF - BMC Genetics

SN - 1471-2156

ER -

Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Abstract

ASJC Scopus subject areas

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