Abstract
Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.
Original language | English (US) |
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Journal | BMC genetics |
Volume | 4 Suppl 1 |
State | Published - 2003 |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)