Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Vincent P. Diego, Laura Almasy, Thomas D. Dyer, Júlia M.P. Soler, John Blangero

    Research output: Contribution to journalArticle

    24 Scopus citations

    Abstract

    Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

    Original languageEnglish (US)
    JournalBMC genetics
    Volume4 Suppl 1
    StatePublished - 2003

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    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

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