Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Vincent P. Diego; Laura Almasy; Thomas D. Dyer; Júlia M P Soler; John Blangero

Strategy and model building in the fourth dimension

a null model for genotype x age interaction as a Gaussian stationary stochastic process.

Vincent P. Diego, Laura Almasy, Thomas D. Dyer, Júlia M P Soler, John Blangero

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

Original language	English (US)
Article number	S34
Journal	BMC Genetics
Volume	4 Suppl 1
State	Published - 2003
Externally published	Yes

Fingerprint

Stochastic Processes

Genotype

Blood Pressure

Fasting

Phenotype

Glucose

Chromosomes, Human, Pair 17

Quantitative Trait Loci

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

Diego, V. P., Almasy, L., Dyer, T. D., Soler, J. M. P., & Blangero, J. (2003). Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process. BMC Genetics, 4 Suppl 1, [S34].

Strategy and model building in the fourth dimension : a null model for genotype x age interaction as a Gaussian stationary stochastic process. / Diego, Vincent P.; Almasy, Laura; Dyer, Thomas D.; Soler, Júlia M P; Blangero, John.

In: BMC Genetics, Vol. 4 Suppl 1, S34, 2003.

Research output: Contribution to journal › Article

Diego, VP, Almasy, L, Dyer, TD, Soler, JMP & Blangero, J 2003, 'Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.', BMC Genetics, vol. 4 Suppl 1, S34.

Diego VP, Almasy L, Dyer TD, Soler JMP, Blangero J. Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process. BMC Genetics. 2003;4 Suppl 1. S34.

Diego, Vincent P. ; Almasy, Laura ; Dyer, Thomas D. ; Soler, Júlia M P ; Blangero, John. / Strategy and model building in the fourth dimension : a null model for genotype x age interaction as a Gaussian stationary stochastic process. In: BMC Genetics. 2003 ; Vol. 4 Suppl 1.

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