Strategies in the prevention of ventilator-associated pneumonia

Diego J. Maselli, Marcos I. Restrepo

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Ventilator-associated pneumonia (VAP) remains a significant problem in the hospital setting, with very high morbidity, mortality, and cost. We performed an evidence-based review of the literature focusing on clinically relevant pharmacological and nonpharmacological interventions to prevent VAP. Owing to the importance of this condition the implementation of preventive measures is paramount in the care of mechanically ventilated patients. There is evidence that these measures decrease the incidence of VAP and improve outcomes in the intensive care unit. A multidisciplinary approach, continued education, and ventilator protocols ensure the implementation of these measures. Future research will continue to investigate cost/benefit relationships, antibiotic resistance, as well as newer technologies to prevent contamination and aspiration in mechanically ventilated patients.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalTherapeutic Advances in Respiratory Disease
Issue number2
StatePublished - Apr 2011


  • ICU-related infections
  • hospital acquired pneumonia
  • preventive measures
  • ventilator associated pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)


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