Strategies for using nonhuman primates in genetic research on multifactorial diseases

John L. VandeBerg, Sarah Williams-Blangero

    Research output: Contribution to journalArticle

    23 Scopus citations

    Abstract

    Multifactorial diseases such as coronary heart disease, cancer, and osteoporosis are of increasing public health concern. Such diseases have a complex etiopathogenesis involving genetic and environmental factors and interactions between these factors. Nonhuman primates are uniquely suited as animal models for complex human diseases because of their close evolutionary relationship to humans. We present the rationale for using nonhuman primates as animal models in research designed to assess the genetic determinants of multifactorial diseases. Strategies and current approaches for the use of nonhuman primate models in genetic research on complex diseases are reviewed.

    Original languageEnglish (US)
    Pages (from-to)146-151
    Number of pages6
    JournalLaboratory animal science
    Volume46
    Issue number2
    StatePublished - 1996

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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