Strain differences in the early development of the thymus-dependent cells: Precocity of T lineage cells in AKR mice as compared to those in C3H mice

C. Katsume, G. Fernandes, K. Iwabuchi, K. Ogasawara, T. Gotohda, R. A. Good, K. Onoe

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Early development of T lineage cells were compared between AKR and C3H mice by using two experimental strategies - neonatal thymectomy (NTx) and bone marrow transplantation (BMT) - between these two strains of mice. After NTx, AKR mice developed less wasting disease and showed better maintenance of several T cell functions. In addition, the response of neonatal spleen cells to PHA and ConA was much greater in AKR mice than in C3H mice. Further, when AKR mice were used as recipients of BMT, cell numbers recovered from thymuses between 2 and 7 weeks after reconstitution were consistently much greater (about 10 times greater) than those from chimeras where C3H mice were used as recipients, regardless of the donor strains of bone marrow cells. However, 4 weeks after BMT the proliferative responses to ConA were consistently higher in the donor-derived thymocytes from chimeras where AKR mice were used as bone marrow donors than in those from chimeras in which C3H were donors. The present findings suggest that these differences may be attributed to characteristics of recipient microenvironment (e.g., thymic stroma) which maintain developing thymocytes and supply them to the peripheral lymphoid tissue. Alternatively the differences may to some degree also be attributable to characteristics of the thymic progenitors themselves, which may determine the rates of maturation of thymocyte functions.

Original languageEnglish (US)
Pages (from-to)313-328
Number of pages16
JournalMicrobiology and Immunology
Volume33
Issue number4
StatePublished - 1989

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Inbred AKR Mouse
Inbred C3H Mouse
Thymus Gland
Thymocytes
Bone Marrow Transplantation
Wasting Syndrome
Thymectomy
Lymphoid Tissue
Bone Marrow Cells
Spleen
Cell Count
Bone Marrow
Maintenance
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology
  • Microbiology (medical)

Cite this

Katsume, C., Fernandes, G., Iwabuchi, K., Ogasawara, K., Gotohda, T., Good, R. A., & Onoe, K. (1989). Strain differences in the early development of the thymus-dependent cells: Precocity of T lineage cells in AKR mice as compared to those in C3H mice. Microbiology and Immunology, 33(4), 313-328.

Strain differences in the early development of the thymus-dependent cells : Precocity of T lineage cells in AKR mice as compared to those in C3H mice. / Katsume, C.; Fernandes, G.; Iwabuchi, K.; Ogasawara, K.; Gotohda, T.; Good, R. A.; Onoe, K.

In: Microbiology and Immunology, Vol. 33, No. 4, 1989, p. 313-328.

Research output: Contribution to journalArticle

Katsume, C, Fernandes, G, Iwabuchi, K, Ogasawara, K, Gotohda, T, Good, RA & Onoe, K 1989, 'Strain differences in the early development of the thymus-dependent cells: Precocity of T lineage cells in AKR mice as compared to those in C3H mice', Microbiology and Immunology, vol. 33, no. 4, pp. 313-328.
Katsume, C. ; Fernandes, G. ; Iwabuchi, K. ; Ogasawara, K. ; Gotohda, T. ; Good, R. A. ; Onoe, K. / Strain differences in the early development of the thymus-dependent cells : Precocity of T lineage cells in AKR mice as compared to those in C3H mice. In: Microbiology and Immunology. 1989 ; Vol. 33, No. 4. pp. 313-328.
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