STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study

M. H. Fenstad, M. P. Johnson, M. Løset, S. B. Mundal, L. T. Roten, I. P. Eide, L. Bjørge, R. K. Sande, Å K. Johansson, T. D. Dyer, S. Forsmo, J. Blangero, E. K. Moses, R. Austgulen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.

Original languageEnglish (US)
Article numbergaq064
Pages (from-to)960-968
Number of pages9
JournalMolecular Human Reproduction
Volume16
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

Decidua
Pre-Eclampsia
Fetal Development
Health
Pregnancy
Single Nucleotide Polymorphism
Gene Expression
Choriocarcinoma
Population
Genes

Keywords

  • Decidua basalis
  • HUNT2
  • Intrauterine growth restriction (IUGR)
  • Preeclampsia
  • STOX genes

ASJC Scopus subject areas

  • Molecular Biology
  • Embryology
  • Cell Biology
  • Genetics
  • Developmental Biology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Fenstad, M. H., Johnson, M. P., Løset, M., Mundal, S. B., Roten, L. T., Eide, I. P., ... Austgulen, R. (2010). STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study. Molecular Human Reproduction, 16(12), 960-968. [gaq064]. https://doi.org/10.1093/molehr/gaq064

STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women : Data from the Second Nord-Trøndelag Health Study. / Fenstad, M. H.; Johnson, M. P.; Løset, M.; Mundal, S. B.; Roten, L. T.; Eide, I. P.; Bjørge, L.; Sande, R. K.; Johansson, Å K.; Dyer, T. D.; Forsmo, S.; Blangero, J.; Moses, E. K.; Austgulen, R.

In: Molecular Human Reproduction, Vol. 16, No. 12, gaq064, 12.2010, p. 960-968.

Research output: Contribution to journalArticle

Fenstad, MH, Johnson, MP, Løset, M, Mundal, SB, Roten, LT, Eide, IP, Bjørge, L, Sande, RK, Johansson, ÅK, Dyer, TD, Forsmo, S, Blangero, J, Moses, EK & Austgulen, R 2010, 'STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study', Molecular Human Reproduction, vol. 16, no. 12, gaq064, pp. 960-968. https://doi.org/10.1093/molehr/gaq064
Fenstad, M. H. ; Johnson, M. P. ; Løset, M. ; Mundal, S. B. ; Roten, L. T. ; Eide, I. P. ; Bjørge, L. ; Sande, R. K. ; Johansson, Å K. ; Dyer, T. D. ; Forsmo, S. ; Blangero, J. ; Moses, E. K. ; Austgulen, R. / STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women : Data from the Second Nord-Trøndelag Health Study. In: Molecular Human Reproduction. 2010 ; Vol. 16, No. 12. pp. 960-968.
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