STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study

M. H. Fenstad, M. P. Johnson, M. Løset, S. B. Mundal, L. T. Roten, I. P. Eide, L. Bjørge, R. K. Sande, Å K. Johansson, T. D. Dyer, S. Forsmo, J. Blangero, E. K. Moses, R. Austgulen

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.

Original languageEnglish (US)
Article numbergaq064
Pages (from-to)960-968
Number of pages9
JournalMolecular Human Reproduction
Volume16
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Decidua basalis
  • HUNT2
  • Intrauterine growth restriction (IUGR)
  • Preeclampsia
  • STOX genes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Molecular Biology
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Cell Biology

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